Limonin

製品コードS2319 バッチS231902

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₆H₃₀O₈

分子量

470.51

CAS No.

1180-71-8

Solubility (25°C)*

体外

DMSO

44 mg/mL (93.51 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.2mg/ml (4.68mM)	Taking the 1 mL working solution as an example, add 50 μL of 44 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.31mg/ml (0.66mM)	Taking the 1 mL working solution as an example, add 50 μL of 6.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
in vitro	Limonin is a furanolactone enriched in citrus fruits, which has antivirus and antitumor ability. This compound inhibits the replication of human immunodeficiency virus-1 (HIV-1) in culture of human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM. ^[1] It also shows antinociceptive and anti-inflammatory effects in vivo. ^[2] This chemical is a potent anti proliferative agent against human hepatoma HepG2 cells via regulation of apoptosis and Wnt signallings. ^[3]

製品説明

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

in vitro

Limonin is a furanolactone enriched in citrus fruits, which has antivirus and antitumor ability. This compound inhibits the replication of human immunodeficiency virus-1 (HIV-1) in culture of human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM. ^[1] It also shows antinociceptive and anti-inflammatory effects in vivo. ^[2] This chemical is a potent anti proliferative agent against human hepatoma HepG2 cells via regulation of apoptosis and Wnt signallings. ^[3]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/14648393/
https://pubmed.ncbi.nlm.nih.gov/9619117/
https://pubmed.ncbi.nlm.nih.gov/23633848/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508]	PubMed: 31595166
Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells via attenuating Stat3-induced cell stemness. [ Biomed Pharmacother, 2019, 118:109366]	PubMed: 31545261
Limonin attenuates the stemness of cervical carcinoma cells by promoting YAP nuclear-cytoplasmic translocation [Zhao W, et al. Food Chem Toxicol, 2019, 125:621-628]	PubMed: 30738134
By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma [Yao J, et al. Onco Targets Ther, 2018, 11:3793-3803]	PubMed: 30013360

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。