Linezolid (PNU-100766)

製品コードS1408 バッチS140801

化学情報

	Synonyms		Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₆H₂₀FN₃O₄
	分子量	337.35	CAS No.	165800-03-3
Solubility (25°C)*	体外	DMSO	68 mg/mL (201.57 mM)
		Ethanol	8 mg/mL (23.71 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.
in vitro	Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. ^[1] Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. ^[2] Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. ^[3] Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. ^[4] Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE. ^[5]

製品説明

Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.

in vitro

Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. ^[1] Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. ^[2] Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. ^[3] Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. ^[4] Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE. ^[5]

プロトコル(参考用のみ)

参考

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カスタマーフィードバック

: Data from [Antimicrob Agents Chemother, 2014, 58(7), 4113-22]

: Data from [Data independently produced by , , Sci Rep, 2016, 6:22571]

: Data from [Data independently produced by , , Int J Antimicrob Agents, 2016, 47(3):195-201]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds [ Molecules, 2023, 28(6)2820]	PubMed: 36985792
Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds [ Molecules, 2023, 28(6), 2820]	PubMed: None
Efficacy of a Novel Antibacterial Agent Exeporfinium Chloride, (XF-73), Against Antibiotic-Resistant Bacteria in Mouse Superficial Skin Infection Models [ Infect Drug Resist, 2023, 16:4867-4879]	PubMed: 37520450
Efficacy of a Novel Antibacterial Agent Exeporfinium Chloride, (XF-73), Against Antibiotic-Resistant Bacteria in Mouse Superficial Skin Infection Models [ Infect Drug Resist, 2023, 16:4867-4879]	PubMed: 37520450
Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis [ mBio, 2022, 13(4):e0167222]	PubMed: 35856639
Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis [ Front Pharmacol, 2022, 13:946058]	PubMed: 36160387
Activity of Drug Combinations against Mycobacterium abscessus Grown in Aerobic and Hypoxic Conditions [ Microorganisms, 2022, 10(7)1421]	PubMed: 35889140
Anti-staphylococcus Antibiotics Interfere With the Transcription of Leucocidin ED Gene in Staphylococcus aureus Strain Newman. [ Front Microbiol, 2020, 11:265]	PubMed: 32194524
Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. [ J Mol Cell Biol, 2019, pii: mjz020]	PubMed: 30860577
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis. [ PLoS One, 2019, 14(10):e0222970]	PubMed: 31589621

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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