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Synonyms | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H20FN3O4 |
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分子量 | 337.35 | CAS No. | 165800-03-3 | |
Solubility (25°C)* | 体外 | DMSO | 67 mg/mL (198.6 mM) | |
Ethanol | 33 mg/mL (97.82 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections. |
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in vitro | Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. [1] Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. [2] Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. [3] Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. [4] Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE. [5] |
Data from [Antimicrob Agents Chemother, 2014, 58(7), 4113-22]
Data from [Data independently produced by , , Sci Rep, 2016, 6:22571]
Data from [Data independently produced by , , Int J Antimicrob Agents, 2016, 47(3):195-201]
Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds [ Molecules, 2023, 28(6)2820] | PubMed: 36985792 |
Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds [ Molecules, 2023, 28(6), 2820] | PubMed: None |
Efficacy of a Novel Antibacterial Agent Exeporfinium Chloride, (XF-73), Against Antibiotic-Resistant Bacteria in Mouse Superficial Skin Infection Models [ Infect Drug Resist, 2023, 16:4867-4879] | PubMed: 37520450 |
Efficacy of a Novel Antibacterial Agent Exeporfinium Chloride, (XF-73), Against Antibiotic-Resistant Bacteria in Mouse Superficial Skin Infection Models [ Infect Drug Resist, 2023, 16:4867-4879] | PubMed: 37520450 |
Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis [ mBio, 2022, 13(4):e0167222] | PubMed: 35856639 |
Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis [ Front Pharmacol, 2022, 13:946058] | PubMed: 36160387 |
Activity of Drug Combinations against Mycobacterium abscessus Grown in Aerobic and Hypoxic Conditions [ Microorganisms, 2022, 10(7)1421] | PubMed: 35889140 |
Anti-staphylococcus Antibiotics Interfere With the Transcription of Leucocidin ED Gene in Staphylococcus aureus Strain Newman. [ Front Microbiol, 2020, 11:265] | PubMed: 32194524 |
Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. [ J Mol Cell Biol, 2019, pii: mjz020] | PubMed: 30860577 |
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis. [ PLoS One, 2019, 14(10):e0222970] | PubMed: 31589621 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。