Loteprednol etabonate

製品コードS1669 バッチS166903

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₄H₃₁ClO₇

分子量

466.95

CAS No.

82034-46-6

Solubility (25°C)*

体外

DMSO

93 mg/mL (199.16 mM)

Ethanol

18 mg/mL (38.54 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
in vitro	Loteprednol etabonate possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. This compound exhibits a binding affinity which is 4.3 times that of dexamethasone, both compounds having a Hill factor close to 1 whereas PJ90 and PJ91 does not show any affinity to the receptor. ^[1]
in vivo	Loteprednol etabonate administrated directly into the joint effectively blocks the inflammatory response. This compound prevents the adverse inflammatory effects of antigen action in a rabbit acute experimental model for arthritis. ^[2] It (oral) reaches the upper GI tract effectively, but not the colon, due to absorption and/or decomposition in rats. ^[3] This chemical shows a rapid, dose-dependent elimination with a total blood clearance (CLtotal) of higher than 60 ml/min/kg in rats. It absorbes systemically, after topical administration, can be rapidly transformed to the inactive metabolites, and eliminates from the body mainly through the bile and urine. ^[4]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/2004037/
https://pubmed.ncbi.nlm.nih.gov/9987798/
https://pubmed.ncbi.nlm.nih.gov/7667192/

https://pubmed.ncbi.nlm.nih.gov/7667193/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Loteprednol etabonate alleviates NLRP3 inflammasome-associated inflammatory diseases in mice by suppressing the transcription of IL-1β [ Int J Biol Macromol, 2025, 306(Pt 3):141644]	PubMed: 40032104

Loteprednol etabonate alleviates NLRP3 inflammasome-associated inflammatory diseases in mice by suppressing the transcription of IL-1β [ Int J Biol Macromol, 2025, 306(Pt 3):141644]

PubMed: 40032104

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。