Magnolol

製品コードS2321 バッチS232102

印刷

化学情報

Synonyms

NSC 293099

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₈H₁₈O₂

分子量

266.33

CAS No.

528-43-8

Solubility (25°C)*

体外

DMSO

53 mg/mL (199.0 mM)

Ethanol

53 mg/mL (199.0 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.650mg/ml (9.95mM)	Taking the 1 mL working solution as an example, add 50 μL of 53 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.300mg/ml (1.13mM)	Taking the 1 mL working solution as an example, add 50 μL of 6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Magnolol（NSC 293099）は、ホオノキ（Magnolia officinalis）の樹皮に見られる生理活性リグナンで、Fungal特性を示します。これは、TNF-αによって誘発されるNF-κB活性化を阻害することができます。
in vitro	Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. This compound preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. It has a more potent enhancing effect on GABA_A receptor alpha2 subunit. This chemical shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.
in vivo	LD50: Mice 2200mg/kg (i.g.).

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/11408830/
https://pubmed.ncbi.nlm.nih.gov/10728656/
https://www.freepatentsonline.com/EP0395294.html

https://pubmed.ncbi.nlm.nih.gov/17240450/

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カスタマーフィードバック

: Data from [Data independently produced by , , Inflamm Res, 2016, 65(1):81-93]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

FGF7/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer [ Mol Oncol, 2022, 16(15):2823-2842]	PubMed: 35726195
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury [ Int Immunopharmacol, 2022, 112:109242]	PubMed: 36152538
Maternal magnolol supplementation alters placental morphology, promotes placental angiogenesis during mid-gestation and improves offspring growth in a pregnant mouse model [ Reprod Biol, 2021, 21(4):100567]	PubMed: 34653815
Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli [ Neoplasia, 2020, 22(11):576-589]	PubMed: 32980776
Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations [ J Chromatogr A, 2020, 1625:461230]	PubMed: 32709311
Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator [Li Z Micromachines, 2018, 9(6)]	PubMed: 30424207
Anti-angiogenic and anti-inflammatory effect of Magnolol in the oxygen-induced retinopathy model. [Yang B, et al. Inflamm Res, 2016, 65(1):81-93]	PubMed: 26547789

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。