Melatonin

製品コードS1204 バッチS120404

印刷

化学情報

Synonyms

NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₃H₁₆N₂O₂

分子量

232.28

CAS No.

73-31-4

Solubility (25°C)*

体外

DMSO

46 mg/mL (198.03 mM)

Ethanol

46 mg/mL (198.03 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	10.000mg/ml (43.05mM)	Taking the 1 mL working solution as an example, add 50 μL of 200 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.
in vitro	Melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. It reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. ^[1] This compound is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. It reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. The substance stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. ^[2] This chemical in cell-free systems has been shown to directly scavenge H2O2, singlet oxygen (1O2) and nitric oxide (NO), with little or no ability to scavenge the superoxide anion radical (O2-) in vitro. It also directly detoxifies the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH), or the activated form of this molecule, ONOOH*. Melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species. ^[3] It inhibits cAMP accumulation in most of the cells examined, but the indole effects on other messengers have been often observed only in one type of the cells or tissue, until now. This compound also regulates the transcription factors, namely, phosphorylation of cAMP-responsive element binding protein and expression of c-Fos. ^[4]
in vivo	Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway

製品説明

Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.

in vitro

Melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. It reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. ^[1]

This compound is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. It reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. The substance stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. ^[2]

This chemical in cell-free systems has been shown to directly scavenge H2O2, singlet oxygen (1O2) and nitric oxide (NO*), with little or no ability to scavenge the superoxide anion radical (O2*-) in vitro. It also directly detoxifies the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH), or the activated form of this molecule, ONOOH*. Melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species. ^[3]

It inhibits cAMP accumulation in most of the cells examined, but the indole effects on other messengers have been often observed only in one type of the cells or tissue, until now. This compound also regulates the transcription factors, namely, phosphorylation of cAMP-responsive element binding protein and expression of c-Fos. ^[4]

in vivo

Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	1.2 mM
	反応時間	24 h
	実験の流れ	Cells were treated with various concentrations of this compound for 24 h.
動物実験	動物モデル	C57BL/6 mice
	投薬量	10 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/11060493/
https://pubmed.ncbi.nlm.nih.gov/9770244/
https://pubmed.ncbi.nlm.nih.gov/11898866/

https://pubmed.ncbi.nlm.nih.gov/9674691/
https://pubmed.ncbi.nlm.nih.gov/36225557/
https://pubmed.ncbi.nlm.nih.gov/32685016/

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カスタマーフィードバック

: , , J Pineal Res. 2017, 62(4), doi: 10.1111/jpi.12383

: Data from [Data independently produced by , , J Pineal Res, 2016, doi: 10.1111/jpi.12383.]

: Data from [Data independently produced by , , Reproduction, 2018, 155(3):307-319]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Zearalenone Exposure Damages Skeletal Muscle Through Oxidative Stress and Is Alleviated by Glutathione, Nicotinamide Mononucleotide, and Melatonin [ Antioxidants (Basel), 2025, 14(5)528]	PubMed: 40427410
Melatonin suppresses PD-L1 expression and exerts antitumor activity in hepatocellular carcinoma [ Sci Rep, 2025, 15(1):8451]	PubMed: 40069331
Melatonin ameliorates ischemic brain injury in experimental stroke by regulation of miR-221 and ATG7 axis [ Biochem Biophys Res Commun, 2025, 760:151706]	PubMed: 40157291
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice [ Heliyon, 2024, 10(18):e38098]	PubMed: 39347399
Ciprofloxacin is a novel anti-ferroptotic antibiotic [ Heliyon, 2024, 10(11):e32571]	PubMed: 38961954
Experimental study on small molecule combinations inducing reprogramming of rat fibroblasts into functional neurons [ Zhejiang Da Xue Xue Bao Yi Xue Ban, 2024, 53(4):498-508]	PubMed: 39183062
Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy [ Ecotoxicol Environ Saf, 2023, 255:114719]	PubMed: 37032573
Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice [ Microbiol Res, 2023, 276:127480]	PubMed: 37659335
Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway [ Cell Oncol (Dordr), 2023, 10.1007/s13402-023-00875-w]	PubMed: 37749430
Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis [ Biomol Ther (Seoul), 2023, 10.4062/biomolther.2023.062]	PubMed: 37183002

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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