Melatonin

製品コードS1204 バッチS120405

化学情報

	Synonyms	NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₃H₁₆N₂O₂
	分子量	232.28	CAS No.	73-31-4
Solubility (25°C)*	体外	DMSO	46 mg/mL (198.03 mM)
		Ethanol	46 mg/mL (198.03 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.
in vitro	Melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. ^[1] Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Melatonin reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. Melatonin stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. ^[2] Melatonin in cell-free systems has been shown to directly scavenge H2O2, singlet oxygen (1O2) and nitric oxide (NO), with little or no ability to scavenge the superoxide anion radical (O2-) in vitro. Melatonin also directly detoxifies the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH), or the activated form of this molecule, ONOOH*. Melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species. ^[3] Melatonin inhibits cAMP accumulation in most of the cells examined, but the indole effects on other messengers have been often observed only in one type of the cells or tissue, until now. Melatonin also regulates the transcription factors, namely, phosphorylation of cAMP-responsive element binding protein and expression of c-Fos. ^[4]
in vivo	Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway

製品説明

Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.

in vitro

Melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. ^[1]

Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Melatonin reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. Melatonin stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. ^[2]

Melatonin in cell-free systems has been shown to directly scavenge H2O2, singlet oxygen (1O2) and nitric oxide (NO*), with little or no ability to scavenge the superoxide anion radical (O2*-) in vitro. Melatonin also directly detoxifies the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH), or the activated form of this molecule, ONOOH*. Melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species. ^[3]

Melatonin inhibits cAMP accumulation in most of the cells examined, but the indole effects on other messengers have been often observed only in one type of the cells or tissue, until now. Melatonin also regulates the transcription factors, namely, phosphorylation of cAMP-responsive element binding protein and expression of c-Fos. ^[4]

in vivo

Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	1.2 mM
	反応時間	24 h
	実験の流れ	Cells were treated with various concentrations of drug for 24 h.
動物実験	動物モデル	C57BL/6 mice
	投薬量	10 mg/kg
	投与方法	i.p.

参考

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カスタマーフィードバック

: , , J Pineal Res. 2017, 62(4), doi: 10.1111/jpi.12383

: Data from [Data independently produced by , , J Pineal Res, 2016, doi: 10.1111/jpi.12383.]

: Data from [Data independently produced by , , Reproduction, 2018, 155(3):307-319]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy [ Ecotoxicol Environ Saf, 2023, 255:114719]	PubMed: 37032573
Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice [ Microbiol Res, 2023, 276:127480]	PubMed: 37659335
Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway [ Cell Oncol (Dordr), 2023, 10.1007/s13402-023-00875-w]	PubMed: 37749430
Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis [ Biomol Ther (Seoul), 2023, 10.4062/biomolther.2023.062]	PubMed: 37183002
Melatonin attenuates polystyrene microplastics induced motor neurodevelopmental defect in zebrafish (Danio rerio) by activating nrf2 - isl2a Axis [ Ecotoxicol Environ Saf, 2022, 241:113754]	PubMed: 35709674
Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO [ Front Pharmacol, 2022, 13:1007006]	PubMed: 36225557
Melatonin alleviates renal injury by activating mitophagy in diabetic nephropathy [ Front Endocrinol (Lausanne), 2022, 13:889729]	PubMed: 35992101
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway [ Reprod Biol Endocrinol, 2022, 20(1):117]	PubMed: 35962432
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin [ J Pineal Res, 2021, 70(3):e12725]	PubMed: 33621367
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity [ Cell Chem Biol, 2021, S2451-9456(21)00442-6]	PubMed: 34672954

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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