Meropenem

製品コードS1381 バッチS138105

化学情報

	Synonyms	SM 7338	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₇H₂₅N₃O₅S
	分子量	383.46	CAS No.	96036-03-2
Solubility (25°C)*	体外	Water	77 mg/mL (200.8 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.
in vitro	Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae. ^[1] This compound is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Its MICs are not significantly influenced by high inocula and the drug is generally bactericidal. It demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases. ^[2] This antibiotic binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus. ^[3] This chemical is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. It has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity. ^[4]
in vivo	Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. This compound significantly increases the urinary excretion of valproate- glucuronide in rabbits. ^[5]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/8543486/
https://pubmed.ncbi.nlm.nih.gov/2808218/
https://pubmed.ncbi.nlm.nih.gov/7768785/

https://pubmed.ncbi.nlm.nih.gov/7652497/
https://pubmed.ncbi.nlm.nih.gov/11683247/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR [ NPJ Antimicrob Resist, 2025, 3(1):12]	PubMed: 39984645

Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR [ NPJ Antimicrob Resist, 2025, 3(1):12]

PubMed: 39984645

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。