Metronidazole

製品コードS1907 バッチS190701

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₆H₉N₃O₃

分子量

171.15

CAS No.

443-48-1

Solubility (25°C)*

体外

DMSO

34 mg/mL (198.65 mM)

Water

12 mg/mL (70.11 mM)

Ethanol

9 mg/mL (52.58 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	合成抗菌剤および抗原虫剤であるニトロイミダゾール系のMetronidazoleは、原虫に対して使用されます。
in vitro	Metronidazole is relatively inactive until it is metabolized within host or microbial cells. It is activated when it receives an electron from ferredoxin or flavodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. This compound damages cells by forming protein and DNA adducts. It has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of this chemical against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. It has played an important role in anaerobic-related infections. This compound has notable effectiveness in treating anaerobic brain abscesses. Its resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. It partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. This compound leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability.

製品説明

合成抗菌剤および抗原虫剤であるニトロイミダゾール系のMetronidazoleは、原虫に対して使用されます。

in vitro

Metronidazole is relatively inactive until it is metabolized within host or microbial cells. It is activated when it receives an electron from ferredoxin or flavodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. This compound damages cells by forming protein and DNA adducts. It has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of this chemical against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. It has played an important role in anaerobic-related infections. This compound has notable effectiveness in treating anaerobic brain abscesses. Its resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. It partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. This compound leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/10390199/
https://pubmed.ncbi.nlm.nih.gov/1720382/
https://pubmed.ncbi.nlm.nih.gov/10960092/

http://www.ncbi.nlm.nih.gov/pubmed/ 14702395

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Sex hormone receptors, calcium-binding protein and Yap1 signaling regulate sex-dependent liver cell proliferation following partial hepatectomy [ Dis Model Mech, 2024, 17(10)dmm050900]	PubMed: 39397390
Activity of Drug Combinations against Mycobacterium abscessus Grown in Aerobic and Hypoxic Conditions [ Microorganisms, 2022, 10(7)1421]	PubMed: 35889140
A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons [ Elife, 2021, 10e69795]	PubMed: 34550070
Intestinal Methicillin-Resistant Staphylococcus aureus Causes Prosthetic Infection via 'Trojan Horse' Mechanism: Evidence From a Rat Model [ Bone Joint Res, 2020, 16;9(4):152-161]	PubMed: 32431806

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。