Milrinone

製品コードS2484 バッチS248401

化学情報

	Synonyms	Win 47203,Primacor	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₂H₉N₃O
	分子量	211.22	CAS No.	78415-72-2
Solubility (25°C)*	体外	DMSO	42 mg/mL (198.84 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
in vitro	Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. ^[1] Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. ^[2] Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. ^[3]
in vivo	Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. ^[4] Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. ^[5] Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. ^[6]

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カスタマーフィードバック

: , , Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The function of Nucleoporin 37 on mouse oocyte maturation and preimplantation embryo development [ J Assist Reprod Genet, 2022, 10.1007/s10815-021-02330-x]	PubMed: 35022896
Glucocorticoid-induced CREB activation and myostatin expression in C2C12 myotubes involves phosphodiesterase-3/4 signaling [Xie Y, et al. Biochem Biophys Res Commun, 2018, 503(3):1409-1414]	PubMed: 30025893
A novel milrinone nanoformulation for use in cardiovascular diseases: preparation and in vitro characterization. [Lomis N, et al. Mol Pharm, 2017, 10.1021/acs.molpharmaceut.7b00360]	PubMed: 28837343

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。