Milrinone

製品コードS2484 バッチS248404

印刷

化学情報

Chemical Structure Synonyms Win 47203,Primacor Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

  C12H9N3O
分子量 211.22 CAS No. 78415-72-2
Solubility (25°C)* 体外 DMSO 42 mg/mL (198.84 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 2.100mg/ml (9.94mM) Taking the 1 mL working solution as an example, add 50 μL of 42 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution
5% DMSO 95% Corn oil

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.300mg/ml (1.42mM) Taking the 1 mL working solution as an example, add 50 μL of 6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
in vitro

Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. This compound inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM. It concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. This chemical concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. [1] It increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. [2] This compound is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. It significant increases in cAMP content accompany significant vasorelaxation. [3]
in vivo

Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.This compound (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. [4] It causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. [5] This chemical leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. [6]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10511123/
  • https://pubmed.ncbi.nlm.nih.gov/8659556/
  • https://pubmed.ncbi.nlm.nih.gov/2845058/
  • https://pubmed.ncbi.nlm.nih.gov/12652111/
  • https://pubmed.ncbi.nlm.nih.gov/8894186/
  • https://pubmed.ncbi.nlm.nih.gov/9066407/

カスタマーフィードバック

, , Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Transcriptional insights on the incomplete cytoplasmic maturation and developmental potential of oocytes cultured without granulosa cells in mice [ BMC Genomics, 2025, 26(1):270] PubMed: 40102748
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
The function of Nucleoporin 37 on mouse oocyte maturation and preimplantation embryo development [ J Assist Reprod Genet, 2022, 10.1007/s10815-021-02330-x] PubMed: 35022896
Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure [ Pharmaceuticals (Basel), 2021, 14(7)697] PubMed: 34358122
Synthesis and characterization of peptide conjugated human serum albumin nanoparticles for targeted cardiac uptake and drug delivery [ PLoS One, 2021, 16(9):e0254305] PubMed: 34591850
Glucocorticoid-induced CREB activation and myostatin expression in C2C12 myotubes involves phosphodiesterase-3/4 signaling [Xie Y, et al. Biochem Biophys Res Commun, 2018, 503(3):1409-1414] PubMed: 30025893
A novel milrinone nanoformulation for use in cardiovascular diseases: preparation and in vitro characterization. [Lomis N, et al. Mol Pharm, 2017, 10.1021/acs.molpharmaceut.7b00360] PubMed: 28837343
Novel Milrinone Nanoformulation for Use in Cardiovascular Diseases: Preparation andin VitroCharacterization [ Mol Pharmaceut, 2017, Vol 15/Issue 7] PubMed: none

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。