Mitoxantrone Dihydrochloride (NSC 301739)

製品コードS2485 バッチS248502

化学情報

	Synonyms	NSC-301739 2HCl, Mitozantrone 2HCl	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₂H₂₉ClN₄O_6.2HCl
	分子量	517.4	CAS No.	70476-82-3
Solubility (25°C)*	体外	DMSO	104 mg/mL (201.0 mM)
		Water	104 mg/mL (201.0 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Mitoxantrone 2HClは、Mitoxantroneの二塩酸塩です。Mitoxantroneは、type II topoisomeraseおよびprotein kinase C (PKC)の阻害剤であり、PKCに対するIC50は8.5 μMです。Mitoxantroneは、MCF-7/wt細胞の増殖をIC50 0.42 μMで阻害します。Mitoxantroneはapoptosisも誘導します。
in vitro	Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. Mitoxantrone activates NFkappaB and stimulates IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60/MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution. Mitoxantrone inhibits proliferation of activated PBMCs, B lymphocytes, or antigen-specific T-cell lines (TCLs) stimulated on antigen-presenting cells (APCs) in a dose-dependent manner. Mitoxantrone induces apoptosis of PBMCs, monocytes and DCs at low concentrations, whereas higher doses causes cell lysis.
in vivo	Mitoxantrone transiently decreases the growth rate of HID xenografts in mice but does not affect that of PAC120 xenografts. Mitoxantrone results in the severity of the cardiac lesions and the nephropathy and the intestinal toxicity in spontaneously hypertensive rats. Mitoxantrone and iron(III) form a strong 2:1 complex, in which mitoxantrone may be acting as a tridentate ligand.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/10328583/
https://pubmed.ncbi.nlm.nih.gov/2476134/
https://pubmed.ncbi.nlm.nih.gov/2287944/

https://pubmed.ncbi.nlm.nih.gov/2476134/
https://pubmed.ncbi.nlm.nih.gov/9664073/
https://pubmed.ncbi.nlm.nih.gov/8254024/
https://pubmed.ncbi.nlm.nih.gov/1295884/

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カスタマーフィードバック

: Data from [Data independently produced by , , Cell, 2018, 174(5):1200-1215]

: Data from [Data independently produced by , , EBioMedicine, 2017, 15:48-61]

: Data from [Data independently produced by , , Electrochimica Acta, 2015, 165:430-442.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Identifying Age-Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age [ Aging Cell, 2025, e70075]	PubMed: 40307992
A functional comparison of two transplantable syngeneic mouse models of melanoma: B16F0 and YUMM1.7 [ Biol Open, 2025, 14(9)bio062175]	PubMed: 40878826
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805]	PubMed: 39581704
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity [ Mol Metab, 2024, 80:101873]	PubMed: 38199601
Mitoxantrone ameliorates ineffective erythropoiesis in a β-thalassemia intermedia mouse model [ Blood Adv, 2024, 8(15):4017-4024]	PubMed: 38861356
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
Visualization strategies to aid interpretation of high-dimensional genotoxicity data [ Environ Mol Mutagen, 2024, 10.1002/em.22604]	PubMed: 38757760
Carbonic anhydrase IX inhibitor S4 triggers release of DAMPs related to immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway [ Cell Commun Signal, 2023, 21(1):167]	PubMed: 37386564
Development of Novel Epigenetic Anti-Cancer Therapy Targeting TET Proteins [ Int J Mol Sci, 2023, 10.3390/ijms242216375]	PubMed: 38003566

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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