受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C36H61NaO11 |
|||
分子量 | 692.85 | CAS No. | 22373-78-0 | |
Solubility (25°C)* | 体外 | Ethanol | 100 mg/mL (144.33 mM) | |
DMSO | Insoluble | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. |
---|---|
in vitro | Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3] |
in vivo | LD50: Mice 335mg/kg (i.g.) [4]; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.). [5] |
Data from [Tuberc Respir Dis, 2013, 75(1), 9-17]
Inhibition of Wnt/β-catenin signaling by monensin in cervical cancer [ Korean J Physiol Pharmacol, 2024, 28(1):21-30] | PubMed: 38154961 |
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer [ Signal Transduct Target Ther, 2022, 7(1):35] | PubMed: 35115484 |
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly [ Nat Commun, 2022, 13(1):4848] | PubMed: 35977928 |
Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment [ Cancer Commun (Lond), 2022, 10.1002/cac2.12311] | PubMed: 35615815 |
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair [ Immunity, 2021, 54(6):1123-1136.e8] | PubMed: 34107271 |
Monensin suppresses cell proliferation and invasion in ovarian cancer by enhancing MEK1 SUMOylation [ Exp Ther Med, 2021, 22(6):1390] | PubMed: 34650638 |
Autophagy-based-unconventional-secretion-of-HMGB1-by-keratinocytes-plays-a-pivotal-role-in-psoriatic-skin-inflammation. [ Autophagy, 2020, 16:1-24] | PubMed: 32019420 |
FOXM1D Potentiates PKM2-mediated tumor glycolysis and angiogenesis [ Mol Oncol, 2020, 10.1002/1878-0261.12879] | PubMed: 33314660 |
The Regulatory Effect of the Kinase Inhibitor PD98059 on Autophagic Flux During Trypsinogen Activation in Pancreatic Acinar Cells. [ Pancreas, 2020, 49(2):290-299] | PubMed: 32011537 |
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734] | PubMed: 32511305 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。