Omeprazole

製品コードS1389 バッチS138901

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C17H19N3O3S
分子量 345.42 CAS No. 73590-58-6
Solubility (25°C)* 体外 DMSO 69 mg/mL (199.75 mM)
Ethanol 15 mg/mL (43.42 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Omeprazoleは、proton pump阻害薬であり、H(+)-K(+)-ATPaseを阻害することで、消化不良、消化性潰瘍、胃食道逆流症、喉頭咽頭逆流症、ゾリンジャー・エリソン症候群の治療に用いられます。
in vitro Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. This compound induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. It causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. This chemical causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. It induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. This agent decreases the activation of osteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect.
in vivo Omeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. This compound temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/9139728/
  • https://pubmed.ncbi.nlm.nih.gov/8795713/
  • https://pubmed.ncbi.nlm.nih.gov/21042782/
  • https://pubmed.ncbi.nlm.nih.gov/8179010/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Species-specific in vivo exposure assessment and in vivo-in vitro correlation of the carboxylate esters prodrug HD56 targeting FK506 binding proteins: The pivotal role of humanized mice [ Drug Metab Dispos, 2025, 53(4):100049] PubMed: 40073534
Proton pump inhibitors enhance macropinocytosis-mediated extracellular vesicle endocytosis by inducing membrane v-ATPase assembly [ J Extracell Vesicles, 2024, 13(4):e12426] PubMed: 38532609
Berberine in combination with evodiamine ameliorates gastroesophageal reflux disease through TAS2R38/TRPV1-mediated regulation of MAPK/NF-κB signaling pathways and macrophage polarization [ Phytomedicine, 2024, 135:156251] PubMed: 39566409
Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer [ J Transl Med, 2024, 22(1):676] PubMed: 39044184
Investigating the therapeutic effects and potential mechanisms of Zuojin Pill in the treatment of gastroesophageal reflux disease [ J Ethnopharmacol, 2024, 340:119230] PubMed: 39662861
Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells [ Theranostics, 2021, 11(5):2364-2380] PubMed: 33500730
Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells [ J Virol, 2021, JVI.00190-21] PubMed: 33731460
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 upregulation [ Biosci Rep, 2021, BSR20200842] PubMed: 33393595
Molecular pathways driving omeprazole nephrotoxicity. [ Redox Biol, 2020, 32:101464] PubMed: 32092686
Inhibition of multiple myeloma‑derived exosomes uptake suppresses the functional response in bone marrow stromal cell. [ Int J Oncol, 2019, 54(3):1061-1070] PubMed: 30664188

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。