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Synonyms | Osthol | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C15H16O3 |
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分子量 | 244.29 | CAS No. | 484-12-8 | |
Solubility (25°C)* | 体外 | DMSO | 49 mg/mL (200.58 mM) | |
Ethanol | 49 mg/mL (200.58 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. |
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in vitro | Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. [1] Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. [2] Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg. [3] |
in vivo | LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.). [4] |
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, , Free Radic Biol Med, 2014, 73:260-9.
, , J Biomed Sci, 2015, 22:63.
Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model [ Oxid Med Cell Longev, 2023, 2023:2975193] | PubMed: 36686380 |
Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage [ Metabolites, 2022, 13(1)3] | PubMed: 36676932 |
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] | PubMed: 31595166 |
Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation [Liu YW, et al. J Biomed Sci, 2015, 22:63] | PubMed: 26231226 |
Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis [Yang SM, et al. Free Radic Biol Med, 2014, 73:260-9] | PubMed: 24858719 |
Characterization of glycosaminoglycan interaction sites and exosite inhibitors of cathepsin K [Haoran Cui, et al. Shandong University, 2014, Haoran Cui] |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。