Pamidronate Disodium

製品コードS1311 バッチS131102

化学情報

	Synonyms	CGP 23339AE	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₃H₉NNa₂O₇P₂
	分子量	279.03	CAS No.	57248-88-1
Solubility (25°C)*	体外	Water	11 mg/mL (39.42 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Pamidronate Disodium (CGP 23339AE) は、骨粗しょう症の予防に使用される窒素含有ビスホスホネートです。Pamidronate Disodium は骨吸収因子の阻害剤です。
in vitro	Pamidronate increases OPG mRNA levels and protein secretion by hOB by up to 2- to 3-fold in a dose-dependent fashion with a maximum effect at 1 µM after 72 hours. Artemisinin prevents the inhibitory effects of the glucocorticoid dexamethasone on OPG mRNA and protein production. This compound induces type I collagen secretion and alkaline phosphatase activity by 2-fold. It has a more pronounced calcium-lowering action than etidronate (etidronic acid) and clodronate (clodronic acid) and provides a longer period of normocalcaemic remission. This chemical dose-dependently inhibits resorption of calcium phosphate films by equine OCLs with an IC(50) of 0.58 μM in one horse. It also dose-dependently inhibits the number of OCLs present in BM cultures after 7 days.
in vivo	Pamidronate Disodium administration significantly suppresses this increase below the control level in the tibia and distal femur of oophorectomized rats. This compound significantly increases bone density and ash weight in both sham-operated and oophorectomized rats. It inhibits all significant effects of growth hormone (GH) and it also decreases the IGF-I levels in rats treated with growth hormone (GH). This chemical itself results in increased the bone density and ash weight of the tibia and decreased urinary DPD excretion.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/11855844/
https://pubmed.ncbi.nlm.nih.gov/1709854/
https://pubmed.ncbi.nlm.nih.gov/12027590/

https://pubmed.ncbi.nlm.nih.gov/9803469/
https://pubmed.ncbi.nlm.nih.gov/10984078/

+ 展开

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice [ Nat Aging, 2023, 10.1038/s43587-023-00512-z]	PubMed: 37946040

CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice [ Nat Aging, 2023, 10.1038/s43587-023-00512-z]

PubMed: 37946040

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。