Phenylephrine HCl

製品コードS2569 バッチS256901

化学情報

	Synonyms	NCI-C55641 HCl,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₉H₁₃NO₂.HCl
	分子量	203.67	CAS No.	61-76-7
Solubility (25°C)*	体外	DMSO	41 mg/mL (201.3 mM)
		Water	41 mg/mL (201.3 mM)
		Ethanol	41 mg/mL (201.3 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
in vitro	Phenylephrine causes a rapid translocation of PKC-epsilon (EC50 = 0.9 mM) but the proportion lost from the soluble fraction is less than with ET-1. ^[1] Phenylephrine at pCa 7 causes a dose-dependent increase in contractile force of the hyperpermeable cells, which is reversible on addition of phentolamine. ^[2] Phenylephrine also protects cardiomyocytes against subsequent 24 h treatment with hypoxia and serum deprivation. Phenylephrine prevents the down-regulation of Bcl-2 and Bcl-X mRNA/protein and induces hypertrophic growth. Phenylephrine-mediated protection is abrogated by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptidic inhibitor LEHD-fmk. ^[3] Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes [e.g., atrial natriuretic factor (ANF)] often associated with cardiac hypertrophy. ^[4] Phenylephrine (1 礛) markedly potentiates HGF-induced hepatocyte DNA synthesis and proliferation. ^[5] Phenylephrine (10 mM) reversibly increases I(Ca,L) (51.3%; n = 40) and shifted peak I(Ca,L) activation voltage by -10 mV. Phenylephrine also increases local, subsarcolemmal SR Ca²⁺ release via IP3-dependent signaling. Phenylephrin-induced NOi release requires stimulation of both PI-3K/Akt and IP3-dependent Ca²⁺ signaling. Phenylephrine-induced NOi release is inhibited by each of 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C. ^[6]

製品説明

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

in vitro

Phenylephrine causes a rapid translocation of PKC-epsilon (EC50 = 0.9 mM) but the proportion lost from the soluble fraction is less than with ET-1. ^[1] Phenylephrine at pCa 7 causes a dose-dependent increase in contractile force of the hyperpermeable cells, which is reversible on addition of phentolamine. ^[2] Phenylephrine also protects cardiomyocytes against subsequent 24 h treatment with hypoxia and serum deprivation. Phenylephrine prevents the down-regulation of Bcl-2 and Bcl-X mRNA/protein and induces hypertrophic growth. Phenylephrine-mediated protection is abrogated by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptidic inhibitor LEHD-fmk. ^[3] Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes [e.g., atrial natriuretic factor (ANF)] often associated with cardiac hypertrophy. ^[4] Phenylephrine (1 礛) markedly potentiates HGF-induced hepatocyte DNA synthesis and proliferation. ^[5] Phenylephrine (10 mM) reversibly increases I(Ca,L) (51.3%; n = 40) and shifted peak I(Ca,L) activation voltage by -10 mV. Phenylephrine also increases local, subsarcolemmal SR Ca²⁺ release via IP3-dependent signaling. Phenylephrin-induced NOi release requires stimulation of both PI-3K/Akt and IP3-dependent Ca²⁺ signaling. Phenylephrine-induced NOi release is inhibited by each of 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C. ^[6]

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: Data from [Data independently produced by , , Stem Cells Dev, 2017, 26(7):528-540]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A modified apical resection model with high accuracy and reproducibility in neonatal mouse and rat hearts [ NPJ Regen Med, 2023, 8(1):9]	PubMed: 36806296
α1-adrenoceptor stimulation ameliorates lipopolysaccharide-induced lung injury by inhibiting alveolar macrophage inflammatory responses through NF-κB and ERK1/2 pathway in ARDS [ Front Immunol, 2022, 13:1090773]	PubMed: 36685596
α1-adrenoceptor stimulation ameliorates lipopolysaccharide-induced lung injury by inhibiting alveolar macrophage inflammatory responses through NF-κB and ERK1/2 pathway in ARDS [ Front Immunol, 2022, 10.3389/fimmu.2022.1090773]	PubMed: 36685596
Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress [ Oxid Med Cell Longev, 2021, 2021:7848027]	PubMed: 33936386
A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs [ Front Pharmacol, 2019, 10:465]	PubMed: 31133853
17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase [ J Biol Chem, 2019, 294(43):15577-15592]	PubMed: 31439665
The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation. [ Sci Adv, 2019, 5(5):eaau0495]	PubMed: 31086810
N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes. [ Mol Med Rep, 2018, 18(2):2142-2152]	PubMed: 29901150
Efficient Differentiation of TBX18+/WT1+ Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds. [Zhao J, et al. Stem Cells Dev, 2017, 26(7):528-540]	PubMed: 27927069

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人間や獣医の診断であるか治療的な使用のためにでない。

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