Phlorizin

製品コードS2343 バッチS234307

印刷

化学情報

Chemical Structure Synonyms Phloridzin Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H24O10
分子量 436.41 CAS No. 60-81-1
Solubility (25°C)* 体外 DMSO 87 mg/mL warmed with 50ºC water bath (199.35 mM)
Ethanol 10 mg/mL warmed with 50ºC water bath (22.91 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
in vitro

Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood. [1] Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine which benefits the treatment of diabetes, obesity, and stress hyperglycemia. [2]

プロトコル(参考用のみ)

カスタマーフィードバック

, , Mol Neurobiol, 2016, 54(5):3825-3842

Data from [Data independently produced by , , Mol Neurobiol, 2017, 54(5):3825-3842 ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay [ Mol Ther Methods Clin Dev, 2022, 24:11-19] PubMed: 34977268
Ginsenoside Rd protects cerebral endothelial cells from oxygen-glucose deprivation/reoxygenation induced pyroptosis via inhibiting SLC5A1 mediated sodium influx [ J Ginseng Res, 2022, 46(5):700-709] PubMed: 36090684
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] PubMed: 31595166
Prompt apoptotic response to high glucose in SGLT-expressing renal cells [ Am J Physiol Renal Physiol, 2019, 316(5):F1078-F1089] PubMed: 30864838
A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells. [ Nat Prod Bioprospect, 2019, 9(1):13-21] PubMed: 30387082
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions [Anandhan A, et al. Mol Neurobiol, 2016, 10.1007/s12035-016-9906-2] PubMed: 27324791
Colloidal Aggregation and the in vitro Activity of Traditional Chinese Medicines. [Duan D, et al. ACS Chem Biol, 2015, 10.1021/cb5009487] PubMed: 25606714

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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