Phlorizin

製品コードS2343 バッチS234309

印刷

化学情報

Synonyms

Phloridzin

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₁H₂₄O₁₀

分子量

436.41

CAS No.

60-81-1

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

87 mg/mL (199.35 mM)

Ethanol (warmed with 50ºC water bath)

87 mg/mL (199.35 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Phlorizin (Phloridzin) は、ナシ (Pyrus communis)、リンゴ、サクランボなどの果樹の樹皮に含まれるジヒドロカルコンです。Phlorizin は、hSGLT1 および hSGLT2 に対してそれぞれ 300 nM および 39 nM の Ki を持つ非選択的SGLT阻害剤です。Phlorizin はNa+/K+-ATPase阻害剤でもあります。
in vitro	Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. This compound is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood. Its principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine which benefits the treatment of diabetes, obesity, and stress hyperglycemia.

製品説明

Phlorizin (Phloridzin) は、ナシ (Pyrus communis)、リンゴ、サクランボなどの果樹の樹皮に含まれるジヒドロカルコンです。Phlorizin は、hSGLT1 および hSGLT2 に対してそれぞれ 300 nM および 39 nM の Ki を持つ非選択的SGLT阻害剤です。Phlorizin はNa+/K+-ATPase阻害剤でもあります。

in vitro

Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. This compound is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood. Its principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine which benefits the treatment of diabetes, obesity, and stress hyperglycemia.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/20602306/
https://pubmed.ncbi.nlm.nih.gov/15624123/
https://pubmed.ncbi.nlm.nih.gov/18063724/

https://pubmed.ncbi.nlm.nih.gov/142763/

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カスタマーフィードバック

: , , Mol Neurobiol, 2016, 54(5):3825-3842

: Data from [Data independently produced by , , Mol Neurobiol, 2017, 54(5):3825-3842 ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay [ Mol Ther Methods Clin Dev, 2022, 24:11-19]	PubMed: 34977268
Ginsenoside Rd protects cerebral endothelial cells from oxygen-glucose deprivation/reoxygenation induced pyroptosis via inhibiting SLC5A1 mediated sodium influx [ J Ginseng Res, 2022, 46(5):700-709]	PubMed: 36090684
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447]	PubMed: 30900754
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508]	PubMed: 31595166
Prompt apoptotic response to high glucose in SGLT-expressing renal cells [ Am J Physiol Renal Physiol, 2019, 316(5):F1078-F1089]	PubMed: 30864838
A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells. [ Nat Prod Bioprospect, 2019, 9(1):13-21]	PubMed: 30387082
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions [Anandhan A, et al. Mol Neurobiol, 2016, 10.1007/s12035-016-9906-2]	PubMed: 27324791
Colloidal Aggregation and the in vitro Activity of Traditional Chinese Medicines. [Duan D, et al. ACS Chem Biol, 2015, 10.1021/cb5009487]	PubMed: 25606714

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。