Piroxicam

製品コードS1713 バッチS171301

印刷

化学情報

Chemical Structure Synonyms CP 16171 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C15H13N3O4S
分子量 331.35 CAS No. 36322-90-4
Solubility (25°C)* 体外 DMSO 60 mg/mL (181.07 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Piroxicam (CP 16171) は、関節リウマチや変形性関節症の治療に用いられる非選択的COX阻害剤です。
in vitro Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. This compound and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures.
in vivo Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. This compound increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. It up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. This chemical combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. It inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and does not have any direct cytotoxic effects in vitro. It also binds strongly to plasma proteins and could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. This agent prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/11208911/
  • https://pubmed.ncbi.nlm.nih.gov/9364001/
  • https://pubmed.ncbi.nlm.nih.gov/7835954/
  • https://pubmed.ncbi.nlm.nih.gov/14765798/
  • https://pubmed.ncbi.nlm.nih.gov/11394830/
  • https://pubmed.ncbi.nlm.nih.gov/7825181/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Lactic acid regulates antitumor immunity in canine invasive urothelial carcinoma [ PLOS One, September 18, 2025, e0332825] PubMed: 40966256
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell Bioscience, April 29, 2023, 76] PubMed: 37120570
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell & Bioscience, April 29, 2023, 76] PubMed: 37120570
Neuroepithelial cell transforming 1 as a key regulator in non-small cell lung cancer: unveiling causal links and therapeutic potentials [ Translational Cancer Research, 2024, 6087-6104] PubMed: 39697721
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell Bioscience, 2023, 76] PubMed: 37120570
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell & Bioscience, 2023, 76] PubMed: 37120570
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell Biosci, 2023, 13(1):76] PubMed: 37120570

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。