Piroxicam

製品コードS1713 バッチS171302

印刷

化学情報

Chemical Structure Synonyms CP 16171 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C15H13N3O4S
分子量 331.35 CAS No. 36322-90-4
Solubility (25°C)* 体外 DMSO 66 mg/mL (199.18 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 3.3mg/ml (9.96mM) Taking the 1 mL working solution as an example, add 50 μL of 66 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution
5% DMSO 95% Corn oil

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.47mg/ml (1.42mM) Taking the 1 mL working solution as an example, add 50 μL of 9.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
in vitro Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. This compound and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures. [1]
in vivo Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. [2] This compound increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. It up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. [3] This chemical combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. [4] It inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and does not have any direct cytotoxic effects in vitro. [5] It also binds strongly to plasma proteins and could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. This agent prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats. [6]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/11208911/
  • https://pubmed.ncbi.nlm.nih.gov/9364001/
  • https://pubmed.ncbi.nlm.nih.gov/7835954/
  • https://pubmed.ncbi.nlm.nih.gov/14765798/
  • https://pubmed.ncbi.nlm.nih.gov/11394830/
  • https://pubmed.ncbi.nlm.nih.gov/7825181/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell Biosci, 2023, 13(1):76] PubMed: 37120570

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。