Prednisolone

製品コードS1737 バッチS173703

印刷

化学情報

Chemical Structure Synonyms NSC-9900 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H28O5
分子量 360.44 CAS No. 50-24-8
Solubility (25°C)* 体外 DMSO 72 mg/mL (199.75 mM)
Ethanol 10 mg/mL (27.74 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
in vitro

Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. [1] This compound reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. [2] Its anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. This compound (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. It also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. This chemical reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice. [3]
in vivo

Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. This compound results in an increased number of diaphragmatic bundles in rats. [4] It induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/7513433/
  • https://pubmed.ncbi.nlm.nih.gov/15196245/
  • https://pubmed.ncbi.nlm.nih.gov/11862126/
  • https://pubmed.ncbi.nlm.nih.gov/8376603/
  • https://pubmed.ncbi.nlm.nih.gov/9472744/

カスタマーフィードバック

, , PLoS One, 2014, 9(12):e111840.

Data from [Data independently produced by , , Leuk Lymphoma, 2014, 55(5):1144-50. ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues [ Molecules, 2024, 29(7)1546] PubMed: 38611825
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer [ Life Sci Alliance, 2023, 6(10)e202302009] PubMed: 37536978
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer [ Life Sci Alliance, 2023, 6(10)e202302009] PubMed: 37536978
Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways [ Front Oncol, 2022, 12:905665] PubMed: 36119546
Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro [ J Immunotoxicol, 2021, 18(1):154-162] PubMed: 34714999
In vitro effect of biological and conventional disease-modifying antirheumatic drugs on fibrocyte differentiation in patients with rheumatoid arthritis and healthy controls [ Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054] PubMed: 34059186
Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels [ Int J Biol Sci, 2020, 16(13):2382-2391] PubMed: 32760206
WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma [ Ther Adv Hematol, 2020, 11:2040620719898373] PubMed: 32010435

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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