Progesterone

製品コードS1705 バッチS170501

印刷

化学情報

Chemical Structure Synonyms NSC 64377, Pregn-4-ene-3,20-dione,NSC 9704 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H30O2
分子量 314.46 CAS No. 57-83-0
Solubility (25°C)* 体外 Ethanol 31.5 mg/mL (100.17 mM)
DMSO 22 mg/mL (69.96 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
in vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. [1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. [2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). [3]
in vivo

Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. [4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. [5]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Biomed Pharmacother, 2019, 109:1578-1585]

Data from [Data independently produced by , , Am J Cancer Res, 2015, 5(10): 3210-3220.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ulipristal acetate, a selective progesterone receptor modulator, induces cell death via inhibition of STAT3/CCL2 signaling pathway in uterine sarcoma [ Biomed Pharmacother, 2023, 168:115792] PubMed: 37924789
Chemical-Empowered Human Adipose-Derived Stem Cells with Lower Immunogenicity and Enhanced Pro-angiogenic Ability Promote Fast Tissue Regeneration [ Stem Cells Transl Med, 2022, 11(5):552-565] PubMed: 35511745
Progesterone/Org Inhibits Lung Adenocarcinoma Cell Growth via Membrane Progesterone Receptor Alpha [ Thorac Cancer, 2020, 10.1111/1759-7714.13528] PubMed: 32529777
Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. [ Mol Cell, 2019, 75(6):1103-1116.e9] PubMed: 31420216
Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism [ EBioMedicine, 2019, 39:540-551] PubMed: 30578080
Metformin inhibits estradiol and progesterone-induced decidualization of endometrial stromal cells by regulating expression of progesterone receptor, cytokines and matrix metalloproteinases [Xiong F Biomed Pharmacother, 2019, 109:1578-1585] PubMed: 30551411
Analyses of circRNA profiling during the development from pre-receptive to receptive phases in the goat endometrium [ J Anim Sci Biotechnol, 2019, 10:34] PubMed: 31049198
mPRα mediates P4/Org OD02-0 to improve the sensitivity of lung adenocarcinoma to EGFR-TKIs via the EGFR-SRC-ERK1/2 pathway. [ Mol Carcinog, 2019, 10.1002/mc.23139] PubMed: 31777985
Progesterone-mediated angiogenic activity of endothelial progenitor cell and angiogenesis in traumatic brain injury rats were antagonized by progesterone receptor antagonist. [ Cell Prolif, 2017, 50(5)] PubMed: 28752929
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells. [Gao K, et al. Am J Cancer Res, 2015, 5(10):3210-20] PubMed: 26693071

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。