Progesterone

製品コードS1705 バッチS170503

印刷

化学情報

Chemical Structure Synonyms NSC 64377, Pregn-4-ene-3,20-dione,NSC 9704 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H30O2
分子量 314.46 CAS No. 57-83-0
Solubility (25°C)* 体外 DMSO 63 mg/mL (200.34 mM)
Ethanol 63 mg/mL (200.34 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Progesteroneは、ヒトおよびその他の種の月経周期、妊娠、および胚発生に関与する内因性ステロイドホルモンです。nuclear progesterone receptor (nPR)の強力なアゴニストであり、Kdは1 nMです。また、membrane progesterone receptors(mPRs)のアゴニストであり、σ1 receptorのアンタゴニストでもあります。
in vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. This compound-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. It drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. This hormone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax).

in vivo

Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. This compound significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. This compound-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/9553133/
  • https://pubmed.ncbi.nlm.nih.gov/20445538/
  • https://pubmed.ncbi.nlm.nih.gov/8392205/
  • https://pubmed.ncbi.nlm.nih.gov/18045930/
  • https://pubmed.ncbi.nlm.nih.gov/7925843/

カスタマーフィードバック

Data from [Data independently produced by , , Biomed Pharmacother, 2019, 109:1578-1585]

Data from [Data independently produced by , , Am J Cancer Res, 2015, 5(10): 3210-3220.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration [ Bone Res, 2025, 13(1):37] PubMed: 40097410
Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors [ Nat Commun, 2024, 15(1):8708] PubMed: 39379362
Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells [ Dev Cell, 2024, S1534-5807(24)00326-5] PubMed: 38823394
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD) [ Mol Med, 2024, 30(1):123] PubMed: 39138434
An Integrated Approach of Bioassays and Non-Target Screening for the Assessment of Endocrine-Disrupting Activities in Tap Water and Identification of Novel Endocrine-Disrupting Chemicals [ Toxics, 2024, 12(4)247] PubMed: 38668470
Ulipristal acetate, a selective progesterone receptor modulator, induces cell death via inhibition of STAT3/CCL2 signaling pathway in uterine sarcoma [ Biomed Pharmacother, 2023, 168:115792] PubMed: 37924789
Chemical-Empowered Human Adipose-Derived Stem Cells with Lower Immunogenicity and Enhanced Pro-angiogenic Ability Promote Fast Tissue Regeneration [ Stem Cells Transl Med, 2022, 11(5):552-565] PubMed: 35511745
Progesterone/Org Inhibits Lung Adenocarcinoma Cell Growth via Membrane Progesterone Receptor Alpha [ Thorac Cancer, 2020, 10.1111/1759-7714.13528] PubMed: 32529777
Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. [ Mol Cell, 2019, 75(6):1103-1116.e9] PubMed: 31420216
Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism [ EBioMedicine, 2019, 39:540-551] PubMed: 30578080

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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