Propylthiouracil

製品コードS1988 バッチS198801

印刷

化学情報

Synonyms

NSC 6498, NSC 70461

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₇H₁₀N₂OS

分子量

170.23

CAS No.

51-52-5

Solubility (25°C)*

体外

DMSO

80 mg/mL (469.95 mM)

Ethanol

19 mg/mL (111.61 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.700mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 34 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.700mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 34 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
in vivo	Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. ^[1] This compound-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. ^[2] It results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. ^[3] This compound-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. ^[4] It dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. ^[5] This compound inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. This treatment significantly increases circulating TSH at both P3 and P7. This exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth. ^[6]

製品説明

Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.

in vivo

Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. ^[1] This compound-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. ^[2] It results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. ^[3] This compound-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. ^[4] It dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. ^[5] This compound inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. This treatment significantly increases circulating TSH at both P3 and P7. This exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth. ^[6]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/16648293/
https://pubmed.ncbi.nlm.nih.gov/18316471/
https://pubmed.ncbi.nlm.nih.gov/21158436/

https://pubmed.ncbi.nlm.nih.gov/12967335/
https://pubmed.ncbi.nlm.nih.gov/14519490/
https://pubmed.ncbi.nlm.nih.gov/22253429/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism [ J Biol Chem, 2020, jbc.RA120.015020]	PubMed: 32913122
A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs. [ BMC Neurosci, 2015, 16:33]	PubMed: 26037485

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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