Quercetin

製品コードS2391 バッチS239105

印刷

化学情報

Synonyms

Sophoretin, C.I. 75720, NSC 9221

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₀O₇

分子量

302.24

CAS No.

117-39-5

Solubility (25°C)*

体外

DMSO

60 mg/mL (198.51 mM)

Ethanol

8 mg/mL (26.46 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
in vitro	Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. This compound is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. ^[1] This chemical inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. ^[2]
in vivo	Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.^[3] LD50: >3000mg/kg (i.g.) ^[4]

製品説明

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.

in vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. This compound is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. ^[1]

This chemical inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. ^[2]

in vivo

Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.^[3]

LD50: >3000mg/kg (i.g.) ^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Sertoli cells
	濃度	0.1 μM
	反応時間	24 h
	実験の流れ	Cells were treated with various concentrations of this compound for 24 h.
動物実験	動物モデル	Mice bearing LNCaP xenografts or PC-3 xenografts
	投薬量	75mg/kg
	投与方法

参考

https://pubmed.ncbi.nlm.nih.gov/19686810/
https://pubmed.ncbi.nlm.nih.gov/9206266/
https://pubmed.ncbi.nlm.nih.gov/26011145/

https://pubmed.ncbi.nlm.nih.gov/36232461/
https://pubmed.ncbi.nlm.nih.gov/36396643/

カスタマーフィードバック

: Data independently produced by Dr. Zhang of Tianjin Medical University, 2011

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A human neuron alzheimer's disease model reveals barriers to senolytic translatability [ Alzheimers Res Ther, 2025, 17(1):176]	PubMed: 40713864
Nano-encapsulated senolytic cocktail attenuates germ cell senescence in female mice [ Cell Mol Life Sci, 2025, 82(1):164]	PubMed: 40249520
Quercetin Inhibits herpes simplex virus 1 Replication in Corneal Epithelium and Suppresses Keratitis Progression [ Virol Sin, 2025, S1995-820X(25)00102-6]	PubMed: 40675379
Discovery of the therapeutic potential of naltriben against glutamate-induced neurotoxicity [ Neurochem Int, 2025, 183:105928]	PubMed: 39756586
Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts [ Sci Adv, 2025, 11(17):eads1875]	PubMed: 40279419
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury [ Cell Metab, 2024, S1550-4131(24)00371-1]	PubMed: 39389061
Increased PTCHD4 expression via m6A modification of PTCHD4 mRNA promotes senescent cell survival [ Nucleic Acids Res, 2024, gkae322]	PubMed: 38721764
Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice [ Clin Transl Med, 2024, 14(5):e1660]	PubMed: 38764260
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium [ JCI Insight, 2024, 9(15)e174888]	PubMed: 38916962
Investigating the potential mechanism and therapeutic effects of SLXG for cholesterol gallstone treatment [ Phytomedicine, 2024, 132:155886]	PubMed: 39059092

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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