Quercetin Dihydrate

製品コードS2347 バッチS234701

印刷

化学情報

 Chemical Structure Synonyms Sophoretin Storage
(From the date of receipt)
3 years -20°C powder
1 years -80°C in solvent
化学式

C15H10O7.2H2O

分子量 338.27 CAS No. 6151-25-3
Solubility (25°C)* 体外 DMSO 67 mg/mL (198.06 mM)
Ethanol 21 mg/mL (62.08 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液(一定の濃度)を調合する

生物活性

製品説明 Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
in vitro

Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects. [1]

in vivo

LD50: Mice 159mg/kg (i.g.) [2]

プロトコル(参考用のみ)

キナーゼアッセイ
細胞アッセイ 細胞株
濃度
反応時間
実験の流れ
動物実験 動物モデル
投薬量
投与方法

カスタマーフィードバック

Data independently produced by , 2011

Selleckの高級品が、幾つかの出版された研究調査結果(以下を含む)で使われた:

Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging [ ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138] PubMed: 35014784
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis [ Nucleic Acids Res, 2021, gkab538] PubMed: 34181735
Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult [ Front Immunol, 2021, 12:649285] PubMed: 34093537
Physicochemical Changes of Deep-Fat-Fried Chicken Drumsticks Treated with Quercetin-in-Edible Coating during Storage Time [ Foods, 2021, 10(2)467] PubMed: 33672567
Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification [ Drug Des Devel Ther, 2021, 15:1075-1089] PubMed: 33727796
Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy [ Molecules, 2021, 26(5)1210] PubMed: 33668293
Quercetin inhibits the proliferation of multiple myeloma cells by upregulating PTPRR expression [ Acta Biochim Biophys Sin (Shanghai), 2021, gmab128] PubMed: 34558606
Quercetin Dihydrate Inhibition of Cardiac Fibrosis Induced by Angiotensin II in Vivo and in Vitro [ Biomed Pharmacother, 2020, 127:110205] PubMed: 32403046
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。