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受注：045-509-1970 |
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化学情報
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Synonyms | SRT501 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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| 化学式 | C14H12O3 |
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| 分子量 | 228.24 | CAS No. | 501-36-0 | ||||
| Solubility (25°C)* | 体外 | DMSO (warmed with 50ºC water bath) | 300 mg/mL (1314.4 mM) | ||||
| Water | Insoluble | ||||||
| Ethanol | Insoluble | ||||||
| 体内 （毎回新しく調製した物を用意してください） |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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溶剤液（一定の濃度）を調合する
生物活性
| 製品説明 | Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis. |
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| in vitro | Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. This compound is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of this compound as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] It is also an activator of sirtuins. This chemical lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, it mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] This compound is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3] |
| in vivo | Resveratrol improves health and survival of mice on a high-calorie diet. This compound (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. It produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. The substance opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] It has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of this chemical as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, it increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. This compound inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] It shows beneficial effects on heart disease. The substance blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. It increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing this chemical in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] It displays anti-inflammatory activity in vivo. This compound significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] It shows beneficial effects on stroke and brain damage. The substance administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5] |
プロトコル(参考用のみ)
| 細胞アッセイ | 細胞株 | Human breast cancer cell MCF-7 |
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| 濃度 | 30-300 μM | |
| 反応時間 | 2 days | |
| 実験の流れ | Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength. |
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| 動物実験 | 動物モデル | Human ovarian xenografts PA-1 |
| 投薬量 | 100 mg/kg | |
| 投与方法 | i.p. daily for consecutive 4 weeks |
参考
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カスタマーフィードバック
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, , Dr. Johanna Weiss of University Hospital Heidelberg
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Data from [Data independently produced by , , Cell Physiol Biochem, 2015, 35: 2255-2271 ]
Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：
| Identifying Age-Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age [ Aging Cell, 2025, e70075] | PubMed: 40307992 |
| MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice [ Biomed Pharmacother, 2025, 190:118393] | PubMed: 40784125 |
| The nonsteroidal anti-inflammatory drug sulindac reverses obesity-driven immunosuppression and triple-negative breast cancer progression [ Breast Cancer Res, 2025, 27(1):186] | PubMed: 41137072 |
| Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling [ Front Immunol, 2025, 16:1515605] | PubMed: 39963142 |
| Bisphenol A induces cellular senescence in SW1353 chondrocytes via miRNA-449a-mediated downregulation of SIRT1 [ Ecotoxicol Environ Saf, 2025, 303:118906] | PubMed: 40848421 |
| Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth [ Int J Mol Sci, 2025, 26(2)851] | PubMed: 39859566 |
| Vitamin A acts as a potent suppressor of selenoprotein P with potential relevance for multivitamin supplementation [ J Nutr Biochem, 2025, 148:110142] | PubMed: 41106613 |
| Cytoprotective role of resveratrol in cigarette smoke-induced pyroptosis through Nrf2 pathway activation [ Cell Stress Chaperones, 2025, 30(5):100107] | PubMed: 40744391 |
| Resveratrol aggravated H2O2-induced the HK-2 cell damage by inhibiting AKT phosphorylation [ PLoS One, 2025, 20(7):e0327135] | PubMed: 40743123 |
| Resveratrol mediated the proliferation and apoptosis of gastric cancer cells by modulating the PI3K/Akt/P53 signaling pathway [ Biochem Biophys Res Commun, 2024, 723:150186] | PubMed: 38830298 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。