Rocuronium Bromide

製品コードS1397 バッチS139701

印刷

化学情報

Chemical Structure Synonyms ORG 9426 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C32H53N2O4.Br
分子量 609.68 CAS No. 119302-91-9
Solubility (25°C)* 体外 DMSO 122 mg/mL (200.1 mM)
Water 122 mg/mL (200.1 mM)
Ethanol 122 mg/mL (200.1 mM)
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Rocuronium Bromide (ORG 9426)は、現代麻酔で用いられる競合的なAchRアンタゴニストです。
in vitro Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively.
in vivo Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/21253831/
  • https://pubmed.ncbi.nlm.nih.gov/25727956/
  • https://pubmed.ncbi.nlm.nih.gov/21733065/
  • https://pubmed.ncbi.nlm.nih.gov/12711837/
  • https://pubmed.ncbi.nlm.nih.gov/16764586/
  • https://pubmed.ncbi.nlm.nih.gov/16426875/
  • https://pubmed.ncbi.nlm.nih.gov/23480130/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The Pharmaceutical Composition of Rocuronium Bromide May Promote Catecholamine Release From PC-12 Cells [ Cureus, 2024, 16(12):e76537] PubMed: 39872597

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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