Rosiglitazone

製品コードS2556 バッチS255603

印刷

化学情報

Synonyms

BRL 49653

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₈H₁₉N₃O₃S

分子量

357.43

CAS No.

122320-73-4

Solubility (25°C)*

体外

DMSO

71 mg/mL (198.64 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.
in vitro	Rosiglitazone markedly increase phosphorylation of threonine 172 within the α subunit of AMPK, with increased AMP:ATP ratio. This compound has been reported to decrease cholesterol synthesis in a number of cell lines in a peroxisome proliferator-activated receptor γ-independent manner. It activates both α1- and α2-containing AMPK complexes, and this leads to a marked increase in the phosphorylation of acetyl-CoA carboxylase. ^[1] This chemical activates PPAR-gamma2 which acts as a dominant inhibitor of osteoblastogenesis in murine bone marrow in vitro.^[2] It increases adiponectin secretion from omental cells up to 2.3-fold higher, whereas secretion from subcutaneous adipose cells is unaffected. ^[3] This compound changes the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes. ^[4]
in vivo	Rosiglitazone administration results in significant bone loss, including a decrease in bone volume, trabecular width, and trabecular number and an increase in trabecular spacing. This compound also leads to a decrease in bone formation rate, with a simultaneous increase in fat content in the bone marrow. It decreases the expression of the osteoblast-specific genes Runx2/Cbfa1, Dlx5, and alpha1(I)collagen, whereas the expression of the adipocyte-specific fatty acid binding protein aP2 is increased. ^[2] This chemical upregulates gene transcripts encoding mitochondrial proteins in white adipocytes from ob/ob mice accompanied by an increase in mitochondrial mass and changes in mitochondrial structure. ^[4]

製品説明

Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.

in vitro

Rosiglitazone markedly increase phosphorylation of threonine 172 within the α subunit of AMPK, with increased AMP:ATP ratio. This compound has been reported to decrease cholesterol synthesis in a number of cell lines in a peroxisome proliferator-activated receptor γ-independent manner. It activates both α1- and α2-containing AMPK complexes, and this leads to a marked increase in the phosphorylation of acetyl-CoA carboxylase. ^[1]

This chemical activates PPAR-gamma2 which acts as a dominant inhibitor of osteoblastogenesis in murine bone marrow in vitro.^[2]

It increases adiponectin secretion from omental cells up to 2.3-fold higher, whereas secretion from subcutaneous adipose cells is unaffected. ^[3]

This compound changes the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes. ^[4]

in vivo

Rosiglitazone administration results in significant bone loss, including a decrease in bone volume, trabecular width, and trabecular number and an increase in trabecular spacing. This compound also leads to a decrease in bone formation rate, with a simultaneous increase in fat content in the bone marrow. It decreases the expression of the osteoblast-specific genes Runx2/Cbfa1, Dlx5, and alpha1(I)collagen, whereas the expression of the adipocyte-specific fatty acid binding protein aP2 is increased. ^[2]

This chemical upregulates gene transcripts encoding mitochondrial proteins in white adipocytes from ob/ob mice accompanied by an increase in mitochondrial mass and changes in mitochondrial structure. ^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Primary neutrophils
	濃度	10 μM
	反応時間
	実験の流れ	Cells were treated with indicated concentration of this compound.
動物実験	動物モデル	Male Sprague dawely rats
	投薬量	5 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/11994296/
https://pubmed.ncbi.nlm.nih.gov/14500573/
https://pubmed.ncbi.nlm.nih.gov/12466369/

https://pubmed.ncbi.nlm.nih.gov/15520860/
https://pubmed.ncbi.nlm.nih.gov/21406603/
https://pubmed.ncbi.nlm.nih.gov/30737476/
https://pubmed.ncbi.nlm.nih.gov/35131600/
https://pubmed.ncbi.nlm.nih.gov/28892640/

+ 展开

カスタマーフィードバック

: Data from [J Leukoc Biol, 2014, 95(4), 587-98]

: Data from [J Leukoc Biol, 2014, 95(4), 587-98]

: Data from [Data independently produced by , , Theranostics, 2018, 8(15):4262-4278]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses [ Nat Commun, 2025, 16(1):6241]	PubMed: 40624080
Compromised Peroxisome Proliferator-Activated Receptor γ-Mediated Impaired Placental Glucose Transport Via the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway Is Associated With Fetal Growth Restriction [ Lab Invest, 2025, 105(4):104103]	PubMed: 39909142
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence [ Nat Commun, 2024, 15(1):1429]	PubMed: 38365899
Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system [ Nat Commun, 2024, 15(1):7991]	PubMed: 39266553
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis [ Research (Wash D C), 2024, 7:0400]	PubMed: 38939042
Inhibition of Selenoprotein I promotes ferroptosis and reverses resistance to platinum chemotherapy by impairing Akt phosphorylation in ovarian cancer [ MedComm (2020), 2024, 5(12):e70033]	PubMed: 39669976
TCP1 expression alters the ferroptosis sensitivity of diffuse large B-cell lymphoma subtypes by stabilising ACSL4 and influences patient prognosis [ Cell Death Dis, 2024, 15(8):611]	PubMed: 39174525
Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation [ J Anim Sci Biotechnol, 2024, 15(1):124]	PubMed: 39350237
Calpain-1 Up-Regulation Promotes Bleomycin-Induced Pulmonary Fibrosis by Activating Ferroptosis [ Am J Pathol, 2024, S0002-9440(24)00356-0]	PubMed: 39326733
Celastrol Stabilizes Glycolipid Metabolism in Hepatic Steatosis by Binding and Regulating the Peroxisome Proliferator-Activated Receptor γ Signaling Pathway [ Metabolites, 2024, 14(1)64]	PubMed: 38276299

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。