Rutin

製品コードS2350 バッチS235002

印刷

化学情報

Synonyms

Rutoside

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₇H₃₀O₁₆

分子量

610.52

CAS No.

153-18-4

Solubility (25°C)*

体外

DMSO

100 mg/mL (163.79 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	5.000mg/ml (8.19mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.700mg/ml (1.15mM)	Taking the 1 mL working solution as an example, add 50 μL of 14 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	ルチン（ルトシド）は、ソバ、タバコ、レンギョウ、アジサイ、ビオラなど、多くの植物に含まれるフラボノール配糖体であり、ヒトの健康に良い影響を与えます。
in vitro	Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human. This compound inhibits platelet aggregation as well as decreases capillary permeability, making the blood thinner and improving circulation. Recent studies show it could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes.
in vivo	LD50: Mice 650mg/kg (i.p.)

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/18410117/
https://pubmed.ncbi.nlm.nih.gov/7482952/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Generation of RNA aptamers against chikungunya virus E2 envelope protein [ J Virol, 2025, e0209524.]	PubMed: 39927773
Differential Effects of Rutin and Its Aglycone Quercetin on Cytotoxicity and Chemosensitization of HCT 116 Colon Cancer Cells to Anticancer Drugs 5-Fluorouracil and Doxorubicin [ Biology (Basel), 2025, 14(5)527]	PubMed: 40427716
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805]	PubMed: 39581704
Exploiting potential molecular compounds for treating testicular seminoma by targeting immune related genes [ Cell Commun Signal, 2024, 22(1):560]	PubMed: 39574183
Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy [ Front Pharmacol, 2023, 14:1290868]	PubMed: 38313075
Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres [ Metabolites, 2022, 12(10)926]	PubMed: 36295828
Rutin increases alpha-tubulin acetylation via histone deacetylase 6 inhibition [ Drug Dev Res, 2022, 10.1002/ddr.21927]	PubMed: 35266183
Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS [ Hum Mol Genet, 2022, ddac116]	PubMed: 35594544
The protective effect of rutin against the cisplatin-induced cochlear damage in vitro [ Neurotoxicology, 2022, 90:102-111]	PubMed: 35304134
Prevention of polycystic ovary syndrome and postmenopausal osteoporosis by inhibiting apoptosis with Shenling Baizhu powder compound [ PeerJ, 2022, 10:e13939]	PubMed: 36325179

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。