受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H12F3N3S |
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分子量 | 335.35 | CAS No. | 305350-87-2 | |
Solubility (25°C)* | 体外 | DMSO | 67 mg/mL (199.79 mM) | |
Ethanol | 33 mg/mL (98.4 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier. |
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in vitro | SL327 is a structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII. [1] |
in vivo | SL327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. [2] SL327 (30 mg/kg) significantly impairs spatial learning in mice. [3] SL327 (50 mg/kg) blocks cocaine-induced properties. [4] |
動物実験 | 動物モデル | Fear conditioning experiments in male Spague-Dawley rats. |
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投薬量 | 10-100 mg/Kg | |
投与方法 | i.p. |
ERK1/2 inhibition disrupts alcohol memory reconsolidation and prevents relapse [ bioRxiv, 2023, 10.1101/2023.12.12.571297] | PubMed: none |
Incongruence between transcriptional and vascular pathophysiological cell states [ Nat Cardiovasc Res, 2023, 2:2023530-549] | PubMed: 37745941 |
Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling [ Metab Brain Dis, 2022, 37(4):1057-1070] | PubMed: 35230626 |
Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD-95 in the hippocampus of CIH rats [ Eur J Neurosci, 2022, 55(6):1471-1482] | PubMed: 35243702 |
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma [ Nat Commun, 2020, 11(1):1556] | PubMed: 32214092 |
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma. [ Nat Commun, 2020, 25;11(1):1556] | PubMed: 32214092 |
Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. [ Neuroscience, 2020, 430:1-11] | PubMed: 32014436 |
High mitogenic stimulation arrests angiogenesis. [ Nat Commun, 2019, 10(1):2016] | PubMed: 31043605 |
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage. [ Dis Model Mech, 2017, 10(3):337-348] | PubMed: 28153846 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。