Salidroside

製品コードS2396 バッチS239603

印刷

化学情報

Chemical Structure Synonyms Rhodioloside Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C14H20O7
分子量 300.3 CAS No. 10338-51-9
Solubility (25°C)* 体外 DMSO 60 mg/mL (199.8 mM)
Water 60 mg/mL (199.8 mM)
Ethanol 22 mg/mL (73.26 mM)
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Rhodiola roseaから単離されたフェニルプロパノイド配糖体であるSalidroside（Rhodioloside）は、幅広い薬理学的特性を持つことが報告されています。
in vitro Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to this compound is different in those cancer cell lines. It could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, this compound resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). This chemical also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. It activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD).
in vivo Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/20309622/
  • https://pubmed.ncbi.nlm.nih.gov/19787459/
  • https://pubmed.ncbi.nlm.nih.gov/22664423/
  • https://pubmed.ncbi.nlm.nih.gov/19814871/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway [ PLoS One, 2024, 19(7):e0306926] PubMed: 38990890
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy [ Mol Med Rep, 2023, 27(2)37] PubMed: 36579660
Network pharmacology approach and experimental verification of salidroside in the treatment of hepatocellular carcinoma [ Research Square, 2023, 10.21203/rs.3.rs-3696850/v1] PubMed: none
The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH [ FASEB J, 2021, 35(12):e22044] PubMed: 34818449
Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury [ Curr Med Sci, 2021, 10.1007/s11596-021-2374-6] PubMed: 34181207
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。