受注:045-509-1970 |
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Synonyms | Cucoline, Kukoline | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C19H23NO4 |
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分子量 | 329.39 | CAS No. | 115-53-7 | |
Solubility (25°C)* | 体外 | DMSO | 65 mg/mL (197.33 mM) | |
Water | 65 mg/mL warmed with 50ºC water bath (197.33 mM) | |||
Ethanol | 65 mg/mL (197.33 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. |
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in vitro | Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. [1] However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. [2] Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. [3] |
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Data from [Data independently produced by , , Int J Oncol, 2016, 48(5):2098-112]
Data from [Data independently produced by , , Mol Pain, 2018, doi:10.1177/1744806918793232]
Data from [Data independently produced by , , Int Immunopharmacol, 2016, 40:492-500.]
Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis [ Sci Rep, 2023, 13(1):3933] | PubMed: 36894604 |
Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis [ Biomed Res Int, 2022, 2022:4914005] | PubMed: 35309179 |
Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy [ Int J Neurosci, 2022, 1-9] | PubMed: 35815397 |
Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway [ Eur J Pharmacol, 2021, 897:173945] | PubMed: 33596416 |
Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer [ Cancer Manag Res, 2021, 13:1189-1204] | PubMed: 33603465 |
Sinomenine-Inhibits-Non-Small-Cell-Lung-Cancer-via-Downregulation-of-Hexokinases-II-Mediated-Aerobic-Glycolysis. [ Onco-Targets-Ther, 2020, 16;13:3209-3221] | PubMed: 32368080 |
Sinomenine inhibits hypoxia induced breast cancer side population cells metastasis by PI3K/Akt/mTOR pathway [ Bioorg Med Chem, 2020, 31:115986] | PubMed: 33412412 |
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] | PubMed: 31595166 |
Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis. [ Biomed Pharmacother, 2019, 113:108759] | PubMed: 30856539 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。