Sinomenine

製品コードS2359 バッチS235904

印刷

化学情報

Synonyms

Cucoline, Kukoline

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₉H₂₃NO₄

分子量

329.39

CAS No.

115-53-7

Solubility (25°C)*

体外

DMSO

65 mg/mL (197.33 mM)

Water (warmed with 50ºC water bath)

65 mg/mL (197.33 mM)

Ethanol

9 mg/mL (27.32 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	3.250mg/ml (9.87mM)	Taking the 1 mL working solution as an example, add 50 μL of 65 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.460mg/ml (1.40mM)	Taking the 1 mL working solution as an example, add 50 μL of 9.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
in vitro	Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. ^[1] However its analgesic action against other kinds of pain is limited. This compound is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. ^[2] Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. ^[3]

製品説明

Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.

in vitro

Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. ^[1] However its analgesic action against other kinds of pain is limited. This compound is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. ^[2] Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. ^[3]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/9080247/
https://pubmed.ncbi.nlm.nih.gov/61710/
https://pubmed.ncbi.nlm.nih.gov/7848335/

カスタマーフィードバック

: Data from [Data independently produced by , , Int J Oncol, 2016, 48(5):2098-112]

: Data from [Data independently produced by , , Mol Pain, 2018, doi:10.1177/1744806918793232]

: Data from [Data independently produced by , , Int Immunopharmacol, 2016, 40:492-500.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Sinomenine attenuates pulmonary fibrosis by downregulating TGF-β1/Smad3, PI3K/Akt and NF-κB signaling pathways [ BMC Pulm Med, 2024, 24(1):229]	PubMed: 38730387
Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis [ Sci Rep, 2023, 13(1):3933]	PubMed: 36894604
Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis [ Biomed Res Int, 2022, 2022:4914005]	PubMed: 35309179
Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy [ Int J Neurosci, 2022, 1-9]	PubMed: 35815397
Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway [ Eur J Pharmacol, 2021, 897:173945]	PubMed: 33596416
Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer [ Cancer Manag Res, 2021, 13:1189-1204]	PubMed: 33603465
Sinomenine-Inhibits-Non-Small-Cell-Lung-Cancer-via-Downregulation-of-Hexokinases-II-Mediated-Aerobic-Glycolysis. [ Onco-Targets-Ther, 2020, 16;13:3209-3221]	PubMed: 32368080
Sinomenine inhibits hypoxia induced breast cancer side population cells metastasis by PI3K/Akt/mTOR pathway [ Bioorg Med Chem, 2020, 31:115986]	PubMed: 33412412
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447]	PubMed: 30900754
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508]	PubMed: 31595166

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。