Sodium Danshensu

製品コードS2401 バッチS240102

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H9O5.Na
分子量 220.15 CAS No. 67920-52-9
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 7 mg/mL (31.79 mM)
Water 2 mg/mL (9.08 mM)
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.
in vitro Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. [2] Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium. [2]
in vivo LD50: Mice 2356.33 mg/kg (i.g.); Rats >1500mg/kg (i.v.). [3]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/17719161/
  • https://pubmed.ncbi.nlm.nih.gov/20228827/
  • https://pubmed.ncbi.nlm.nih.gov/20843270/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Suppression of Macrophage Activation by Sodium Danshensu via HIF-1α/STAT3/NLRP3 Pathway Ameliorated Collagen-Induced Arthritis in Mice [ Molecules, 2023, 28(4)1551] PubMed: 36838542
Sodium danshensu attenuates cerebral ischemia-reperfusion injury by targeting AKT1 [ Front Pharmacol, 2022, 13:946668] PubMed: 36188542
Sodium danshensu attenuates cerebral ischemia-reperfusion injury by targeting AKT1 [ Front Pharmacol, 2022, 13:946668] PubMed: 36188542
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。