Sodium butyrate

製品コードS1999 バッチS199902

印刷

化学情報

Chemical Structure Synonyms NaB, Butanoic acid sodium salt Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C4H7NaO2
分子量 110.09 CAS No. 156-54-7
Solubility (25°C)* 体外 Water 22 mg/mL (199.83 mM)
Ethanol 8 mg/mL (72.66 mM)
DMSO Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.
in vitro Butyrate mediates growth inhibition of colonic cancer cells and thereby to elucidate the molecular link between a high-fiber diet and the arrest of colon carcinogenesis. Butyrate induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. [1] Sodium butyrate, at physiological concentrations, induces apoptosis in 2 adenoma cell lines, RG/C2 and AA/Cl, and in the carcinoma cell line PC/JW/FI. [2] Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. [3] Butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10. Butyrate also is the most effective fatty acid in stimulating or repressing the expression of specific genes. [4]
in vivo Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). Sodium butyrate also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity. [5]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [PLoS Biol, 2014, 12(1), e1001758]

Data from [Data independently produced by Br J Haematol, 2014, 167(5), 639-50]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] PubMed: 37712417
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] PubMed: 37712417
Regulation of Hsa-miR-4639-5p expression and its potential role in the pathogenesis of Parkinson's disease [ Aging Cell, 2023, 22(6):e13840] PubMed: 37101349
Synergistic effect of sodium butyrate and oxaliplatin on colorectal cancer [ Transl Oncol, 2023, 27:101598] PubMed: 36512976
HDAC-Specific Inhibitors Induce the Release of Porcine Epidemic Diarrhea Virus via the COPII-Coated Vesicles [ Viruses, 2023, 15(9)1874] PubMed: 37766280
Zearalenone disturbs the reproductive-immune axis in pigs: the role of gut microbial metabolites [ Microbiome, 2022, 10(1):234] PubMed: 36536466
Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation [ J Exp Clin Cancer Res, 2022, 41(1):111] PubMed: 35346324
Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling [ Int J Mol Sci, 2022, 23(24)15506] PubMed: 36555149
Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules [ Int J Mol Sci, 2022, 23(8)4213] PubMed: 35457029
AP-1 activity is a major barrier of human somatic cell reprogramming [ Cell Mol Life Sci, 2021, 10.1007/s00018-021-03883-x] PubMed: 34181046

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。