Sodium butyrate

製品コードS1999 バッチS199904

印刷

化学情報

Chemical Structure Synonyms NaB, Butanoic acid sodium salt Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C4H7NaO2
分子量 110.09 CAS No. 156-54-7
Solubility (25°C)* 体外 Water 22 mg/mL (199.83 mM)
Ethanol 22 mg/mL (199.83 mM)
DMSO Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Sodium butyrate (NaB、酪酸ナトリウム塩) は酪酸のナトリウム塩であり、histone deacetylase阻害剤であり、クラスIおよびIIのhistone deacetylase (HDACs) の亜鉛結合部位に競合的に結合します。Sodium butyrate (NaB) は、細胞周期の進行を阻害し、分化を促進し、いくつかの種類の癌細胞においてapoptosisおよびautophagyを誘導します。
in vitro Butyrate mediates growth inhibition of colonic cancer cells and thereby to elucidate the molecular link between a high-fiber diet and the arrest of colon carcinogenesis. This compound induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. Sodium butyrate, at physiological concentrations, induces apoptosis in 2 adenoma cell lines, RG/C2 and AA/Cl, and in the carcinoma cell line PC/JW/FI. It exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. This chemical inhibits most HDAC except class III HDAC and class II HDAC6 and -10. It also is the most effective fatty acid in stimulating or repressing the expression of specific genes.
in vivo Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). This compound also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/9618491/
  • https://pubmed.ncbi.nlm.nih.gov/8397167/
  • https://pubmed.ncbi.nlm.nih.gov/17973645/
  • https://pubmed.ncbi.nlm.nih.gov/12840228/
  • https://pubmed.ncbi.nlm.nih.gov/14561870/
  • https://pubmed.ncbi.nlm.nih.gov/649576/

カスタマーフィードバック

Data from [PLoS Biol, 2014, 12(1), e1001758]

Data from [Data independently produced by Br J Haematol, 2014, 167(5), 639-50]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Revitalizing the Epigenome of Adult Jaw Periosteal Cells: Enhancing Diversity in iPSC-Derived Mesenchymal Stem Cells (iMSCs) [ Cells, 2025, 14(9)627] PubMed: 40358151
Bacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence [ Nat Commun, 2024, 15(1):4764] PubMed: 38834561
Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors [ Nat Commun, 2024, 15(1):5209] PubMed: 38890388
SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability [ Cell Rep, 2024, 43(2):113778] PubMed: 38341854
Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway [ Antioxidants (Basel), 2024, 13(2)140] PubMed: 38397738
Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells [ Int J Mol Sci, 2024, 25(17)9600] PubMed: 39273544
Butyrate attenuates the stemness of lung cancer cells through lysosome Fe2+- and SLC7A11-mediated ferroptosis [ Heliyon, 2024, 10(7):e28093] PubMed: 38560222
Sodium butyrate protect bone mass in lipopolysaccharide-treated rats by reducing oxidative stress and inflammatory [ Redox Rep, 2024, 29(1):2398891] PubMed: 39284587
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] PubMed: 37712417
Regulation of Hsa-miR-4639-5p expression and its potential role in the pathogenesis of Parkinson's disease [ Aging Cell, 2023, 22(6):e13840] PubMed: 37101349

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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