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Synonyms | NaB, Butanoic acid sodium salt | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C4H7NaO2 |
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分子量 | 110.09 | CAS No. | 156-54-7 | |
Solubility (25°C)* | 体外 | Water | 22 mg/mL (199.83 mM) | |
Ethanol | 22 mg/mL (199.83 mM) | |||
DMSO | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells. |
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in vitro | Butyrate mediates growth inhibition of colonic cancer cells and thereby to elucidate the molecular link between a high-fiber diet and the arrest of colon carcinogenesis. Butyrate induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. [1] Sodium butyrate, at physiological concentrations, induces apoptosis in 2 adenoma cell lines, RG/C2 and AA/Cl, and in the carcinoma cell line PC/JW/FI. [2] Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. [3] Butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10. Butyrate also is the most effective fatty acid in stimulating or repressing the expression of specific genes. [4] |
in vivo | Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). Sodium butyrate also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity. [5] |
Data from [PLoS Biol, 2014, 12(1), e1001758]
Data from [Data independently produced by Br J Haematol, 2014, 167(5), 639-50]
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] | PubMed: 37712417 |
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] | PubMed: 37712417 |
Regulation of Hsa-miR-4639-5p expression and its potential role in the pathogenesis of Parkinson's disease [ Aging Cell, 2023, 22(6):e13840] | PubMed: 37101349 |
Synergistic effect of sodium butyrate and oxaliplatin on colorectal cancer [ Transl Oncol, 2023, 27:101598] | PubMed: 36512976 |
HDAC-Specific Inhibitors Induce the Release of Porcine Epidemic Diarrhea Virus via the COPII-Coated Vesicles [ Viruses, 2023, 15(9)1874] | PubMed: 37766280 |
Zearalenone disturbs the reproductive-immune axis in pigs: the role of gut microbial metabolites [ Microbiome, 2022, 10(1):234] | PubMed: 36536466 |
Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation [ J Exp Clin Cancer Res, 2022, 41(1):111] | PubMed: 35346324 |
Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling [ Int J Mol Sci, 2022, 23(24)15506] | PubMed: 36555149 |
Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules [ Int J Mol Sci, 2022, 23(8)4213] | PubMed: 35457029 |
AP-1 activity is a major barrier of human somatic cell reprogramming [ Cell Mol Life Sci, 2021, 10.1007/s00018-021-03883-x] | PubMed: 34181046 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。