受注:045-509-1970 |
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Synonyms | Sodium valproate,NSC 93819,2-Propylpentanoic Acid | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C8H15NaO2 |
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分子量 | 166.19 | CAS No. | 1069-66-5 | |
Solubility (25°C)* | 体外 | DMSO | 33 mg/mL (198.56 mM) | |
Water | 33 mg/mL (198.56 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Valproic Acid sodium is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. |
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in vitro | Valproic acid acts through a distinct pathway that involves direct inhibition of histone deacetylase (IC(50) for HDAC1 = 0.4 mM). Valproic acid mimics the histone deacetylase inhibitor trichostatin A, causing hyperacetylation of histones in cultured cells. Valproic acid, like trichostatin A, also activates transcription from diverse exogenous and endogenous promoters. Valproic acid and trichostatin A have remarkably similar teratogenic effects in vertebrate embryos, while non-teratogenic analogues of valproic acid do not inhibit histone deacetylase and do not activate transcription. [1] Valproic acid induces proliferation of peroxisomes in the rodent liver. Valproic acid at a concentration of 1 mM induces relief of this repression by Gal4 fusions of N‐CoR, TR or PPARδ in a cell line expressing the ligand‐binding domain of PPARδ fused to the DNA‐binding domain of the glucocorticoid receptor (GR) together with a GR‐controlled reporter gene. Valproic acid induces accumulation of hyperacetylated histone and inhibits HDAC activity. Valproic acid induces a specific type of differentiation characterized by reduced proliferation, morphological alterations, marker gene expression and particularly the accumulation of the AP-2 transcription factor as a potential marker of neuronal or neural crest cell-like differentiation in F9 teratocarcinoma cells. Valproic acid impairs cell proliferation or survival as indicated by decreased incorporation of [3H]thymidine in F9 and P19 teratocarcinoma cells. [2] |
in vivo | Valproic acid delays growth of the primary tumors in the MT‐450 rat breast cancer model. [2] |
細胞アッセイ | 細胞株 | HeLa cells |
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濃度 | IC50 of 0.54, 2.8, and 2.4 mM for HDAC2, HDAC5, and HDAC6, respectively. | |
反応時間 | 12 h | |
実験の流れ | Cells were treated with various concentrations of drug for 12 h. |
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動物実験 | 動物モデル | MT-450 rat breast cancer model |
投薬量 | 1.25 mM/kg | |
投与方法 | i.p. |
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Data independently produced by , 2011, Dr. Zhang of Tianjin Medical University
Data from [Data independently produced by , , Front Immunol, 2017, 7:696]
Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice [ Sci Total Environ, 2022, 838(Pt 2):155825] | PubMed: 35597360 |
TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice [ Acta Pharmacol Sin, 2022, 10.1038/s41401-022-00932-4] | PubMed: 35794374 |
Human forebrain organoids reveal connections between valproic acid exposure and autism risk [ Transl Psychiatry, 2022, 12(1):130] | PubMed: 35351869 |
HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs [ Sci China Life Sci, 2021, 10.1007/s11427-020-1855-4] | PubMed: 33420926 |
Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines [ Front Immunol, 2021, 12:771453] | PubMed: 34880868 |
Axitinib and HDAC Inhibitors Interact to Kill Sarcoma Cells [ Front Oncol, 2021, 11:723966] | PubMed: 34604061 |
Neratinib kills B-RAF V600E melanoma via ROS-dependent autophagosome formation and death receptor signaling [ Pigment Cell Melanoma Res, 2021, 10.1111/pcmr.13014] | PubMed: 34482636 |
Effects of signaling pathway inhibitors on hematopoietic stem cells [ Mol Med Rep, 2021, 23(1)9] | PubMed: 33179097 |
HDAC6 Is Involved in the Histone Deacetylation of In Vitro Maturation Oocytes and the Reprogramming of Nuclear Transplantation in Pig [ Reprod Sci, 2021, 10.1007/s43032-021-00533-2] | PubMed: 33725312 |
HDAC6-specific Inhibitor Suppresses Th17 Cell Function via the HIF-1α Pathway in Acute Lung Allograft Rejection in Mice [ Theranostics, 2020, 10(15):6790-6805] | PubMed: 32550904 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。