Suprofen

製品コードS1761 バッチS176101

印刷

化学情報

Chemical Structure Synonyms TN-762 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C14H12O3S
分子量 260.31 CAS No. 40828-46-4
Solubility (25°C)* 体外 DMSO 52 mg/mL (199.76 mM)
Ethanol 52 mg/mL (199.76 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Suprofen(TN-762)は、非ステロイド性抗炎症鎮痛薬および解熱薬として使用される二重COX-1/COX-2阻害剤です。
in vitro

Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. This compound is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. It photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. This chemical sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Its-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. Its incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%).

in vivo

Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that this compound also antagonizes PGF2 alpha receptor binding. This chemical are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. It (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/14570769/
  • https://pubmed.ncbi.nlm.nih.gov/21523348/
  • https://pubmed.ncbi.nlm.nih.gov/1342189/
  • https://pubmed.ncbi.nlm.nih.gov/15063031/
  • https://pubmed.ncbi.nlm.nih.gov/6801733/
  • https://pubmed.ncbi.nlm.nih.gov/8725816/
  • https://pubmed.ncbi.nlm.nih.gov/3774127/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。