Tanshinone I

製品コードS2364 バッチS236404

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₈H₁₂O₃

分子量

276.29

CAS No.

568-73-0

Solubility (25°C)*

体外

DMSO

Insoluble

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.200mg/ml (0.72mM)	Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.200mg/ml (0.72mM)	Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
in vitro	Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. This compound inhibits PGE₂ formation from LPS-induced RAW macrophages (IC50 = 38 μM). However, this compound does not affect COX-2 activity or COX-2 expression. It is an inhibitor of type IIA human recombinant phospholipase A₂ (PLA₂) with IC50 of 11 μM. ^[1] In preliminary data, this chemical possesses the strongest inhibitory effect on tumor necrosis factor-α (TNF-α)-induced adhesion molecules. ^[2]

製品説明

Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.

in vitro

Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. This compound inhibits PGE₂ formation from LPS-induced RAW macrophages (IC50 = 38 μM). However, this compound does not affect COX-2 activity or COX-2 expression. It is an inhibitor of type IIA human recombinant phospholipase A₂ (PLA₂) with IC50 of 11 μM. ^[1] In preliminary data, this chemical possesses the strongest inhibitory effect on tumor necrosis factor-α (TNF-α)-induced adhesion molecules. ^[2]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/12410540/
https://pubmed.ncbi.nlm.nih.gov/18586687/

カスタマーフィードバック

: Data from [Data independently produced by , , Oncotarget, 2015, 6(18):16031-42.]

: Data from [Data independently produced by , , Biochem Pharmacol, 2018, 154:255-264]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma [ Int J Oncol, 2023, 63(1)76]	PubMed: 37203411
Tanshinone I inhibits metastasis of cervical cancer cells by inducing BNIP3/NIX-mediated mitophagy and reprogramming mitochondrial metabolism [ Phytomedicine, 2022, 98:153958]	PubMed: 35124382
Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α [ Drug Des Devel Ther, 2022, 16:3197-3213]	PubMed: 36158238
Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression [ Mol Med Rep, 2021, 23(1)40]	PubMed: 33179075
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447]	PubMed: 30900754
A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza. [ Int Immunopharmacol, 2019, 10.1016/j.intimp.2019.106040]	PubMed: 31818704
Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity [Qin J Biomed Pharmacother, 2018, 105:758-765]	PubMed: 29909343
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis [Tian QT Biochem Pharmacol, 2018, 154:255-264]	PubMed: 29753750
Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage. [ Mol Brain, 2017, 10(1):52]	PubMed: 29137683
Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells [Wang Y, et al. Oncotarget, 2015, 6(18):16031-42]	PubMed: 26202747

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。