Tazarotene

製品コードS1569 バッチS156903

印刷

化学情報

Chemical Structure Synonyms AGN190168 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H21NO2S
分子量 351.46 CAS No. 118292-40-3
Solubility (25°C)* 体外 DMSO 70 mg/mL (199.16 mM)
Ethanol 9 mg/mL (25.6 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
in vitro Tazarotene causes ERK activation, RB tumor suppressor protein hypophosphorylation, G0 arrest, and myeloid differentiation in HL-60 human myeloblastic leukemia cells. This compound could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with an RARalpha-selective ligand. [1] It regulates gene transcription via interaction with specific nuclear retinoic acid receptors (RARs), thereby modulating the three key pathogenic factors in psoriasis. [2] This chemical inhibits the proliferation of fibroblasts and synthesis of DNA and collagen. [3] It down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. This agent also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect. [4] It causes growth suppression in retinoid-responsive breast cancer cell lines by up-regulating TIG3. [5]
in vivo Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in UV-treated Ptch1+/− mice. This compound also reduces the number and size of microscopic basal cell carcinomas (BCCs) in ionizing radiation-treated Ptch1+/− mice. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/15383624/
  • https://pubmed.ncbi.nlm.nih.gov/15989518/
  • https://pubmed.ncbi.nlm.nih.gov/9593227/
  • https://pubmed.ncbi.nlm.nih.gov/9270552/
  • https://pubmed.ncbi.nlm.nih.gov/15231643/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System [ Int J Mol Sci, 2022, 23(16)9366] PubMed: 36012634
Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. [ Mol Pharm, 2015, 12(9):3399-407] PubMed: 26262434
Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. [Yin S J Clin Invest, 2013, 123(9):3941-51] PubMed: 23925292

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。