Teicoplanin

製品コードS1399 バッチS139901

印刷

化学情報

Chemical Structure Synonyms Teichomycin,Targocid,MDL-507 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C77H77N9O31Cl2·R
分子量 1709.39 CAS No. 61036-62-2
Solubility (25°C)* 体外 Water 342 mg/mL (200.07 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Teicoplanin (Teichomycin,Targocid,MDL-507) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
in vitro

Teicoplanin is associated with small increases in the GI colonization by C. albicans. [1] The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell. [2] Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis. [3] Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. [4]
in vivo

Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L [ Front Microbiol, 2022, 13:884034] PubMed: 35572668
Vibrational Optical Activity Study of Four Antibiotic (Lipo)glycopeptides: Vancomycin, Oritavancin, Dalbavancin, and Teicoplanin [ ACS Omega, 2022, 7(48):43657-43664] PubMed: 36506196
Light-Excited Antibiotics for Potentiating Bacterial Killing via Reactive Oxygen Species Generation [ ACS Appl Mater Interfaces, 2020, 12(14):16150-16158] PubMed: 32202405
Relative effectiveness of azithromycin in killing intracellular Porphyromonas gingivalis. [ Clin Exp Dent Res, 2016, 2(1):35-43] PubMed: 29744147

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。