Telmisartan

製品コードS1738 バッチS173803

印刷

化学情報

Chemical Structure Synonyms BIBR 277 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C33H30N4O2
分子量 514.62 CAS No. 144701-48-4
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 15 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.750mg/ml (1.46mM) Taking the 1 mL working solution as an example, add 50 μL of 15 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution
5% DMSO 95% Corn oil

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.090mg/ml (0.17mM) Taking the 1 mL working solution as an example, add 50 μL of 1.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
in vitro Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. This compound induces adipocyte differentiation of 3T3-L1 cells. It causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] This chemical, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. It decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. This compound dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] It effectively facilitates differentiation of 3T3-L1 preadipocytes. This chemical causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. It attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3]
in vivo Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. This compound reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/15007034/
  • https://pubmed.ncbi.nlm.nih.gov/17004092/
  • https://pubmed.ncbi.nlm.nih.gov/15498586/
  • https://pubmed.ncbi.nlm.nih.gov/16567593/

カスタマーフィードバック

, , Sci Rep, 2015, 5:8116.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Differential expression of PPARγ by pioglitazone and telmisartan causes effect of disparity on mTORC2-mediated cell proliferation and migration [ Sci Rep, 2025, 15(1):22112] PubMed: 40594875
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
Anti-tumor effects of telmisartan in glioma-astrocyte non-contact co-cultures: A critical role of astrocytic IL-6-mediated paracrine growth promotion [ Int Immunopharmacol, 2024, 139:112707] PubMed: 39032472
GPCR Inhibitors Have Antiviral Properties against JC Polyomavirus Infection [ Viruses, 2024, 16(10)1559] PubMed: 39459893
Antiviral activity evaluation of pharmaceutical drugs, newly synthesized compounds and fragments against SARS-CoV-2 in vitro [ UNIVERSITY OF PÉCS, 2023, ] PubMed: None
Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats [ Exp Ther Med, 2022, 23(3):216] PubMed: 35126719
Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice [ Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X] PubMed: 34562639
Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation [ Eur J Pharmacol, 2021, S0014-2999(21)00845-1] PubMed: 34919891
Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway. [ Sci Rep, 2019, 9(1):18177] PubMed: 31796785
Brain Renin-Angiotensin System Blockade Attenuates Methamphetamine-Induced Hyperlocomotion and Neurotoxicity [Jiang L, et al. Neurotherapeutics, 2018, 15(2):500-510] PubMed: 29464572

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。