Tetrandrine

製品コードS2403 バッチS240305

印刷

化学情報

Chemical Structure Synonyms NSC-77037, Fanchinine, d-Tetrandrine Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C38H42N2O6
分子量 622.75 CAS No. 518-34-3
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 2 mg/mL (3.21 mM)
Ethanol 2 mg/mL (3.21 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
in vitro

Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. This compound is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. [1] Another study shows that it also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. [2] This chemical inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. [3]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/1331975/
  • https://pubmed.ncbi.nlm.nih.gov/15000886/
  • https://pubmed.ncbi.nlm.nih.gov/9042394/

カスタマーフィードバック

Data from [Data independently produced by , , FASEB J, 2018, 32(6):3398-3410]

Data from [Data independently produced by , , Biochemical and Biophysical Research Communications, 2016, 476(4):481-486.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection [ PLoS Pathog, 2025, 21(8):e1013342] PubMed: 40758737
Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer [ Pharmacol Res, 2024, 207:107314] PubMed: 39059614
Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels [ mBio, 2024, e0228723.] PubMed: 38349185
Insights into the Identification of iPSC- and Monocyte-Derived Macrophage-Polarizing Compounds by AI-Fueled Cell Painting Analysis Tools [ Int J Mol Sci, 2024, 25(22)12330] PubMed: 39596395
Tetrandrine (TET) inhibits African swine fever virus entry into cells by blocking the PI3K/Akt pathway [ Virus Res, 2024, 339:199258] PubMed: 37923171
Tetrandrine inhibits osteoclast differentiation by inducing autophagy [ Chinese Journal of Tissue Engineering Research, 2023, (28): 4473-4479.] PubMed: None
Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis [ Res Sq, 2023, rs.3.rs-3154465] PubMed: 37693580
Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis [ Res Sq, 2023, rs.3.rs-3154465] PubMed: 37693580
Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL [ Mol Med, 2022, 28(1):141] PubMed: 36435772
Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER Stress [ Biomolecules, 2022, 12(6)843] PubMed: 35740967

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。