Tetrandrine

製品コードS2403 バッチS240306

印刷

化学情報

Chemical Structure Synonyms NSC-77037, Fanchinine, d-Tetrandrine Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C38H42N2O6
分子量 622.75 CAS No. 518-34-3
Solubility (25°C)* 体外 DMSO 7 mg/mL warmed with 50ºC water bath (11.24 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
in vitro Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. [1] Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. [2] Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. [3]
in vivo LD50: Mice 158.9mg/kg (i.v.) [4], 365mg/kg (i.p.) [5]; Rats 646mg/kg (i.g.) [6]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , FASEB J, 2018, 32(6):3398-3410]

Data from [Data independently produced by , , Biochemical and Biophysical Research Communications, 2016, 476(4):481-486.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels [ mBio, 2024, e0228723.] PubMed: 38349185
Tetrandrine (TET) inhibits African swine fever virus entry into cells by blocking the PI3K/Akt pathway [ Virus Res, 2024, 339:199258] PubMed: 37923171
Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis [ Res Sq, 2023, rs.3.rs-3154465] PubMed: 37693580
Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis [ Res Sq, 2023, rs.3.rs-3154465] PubMed: 37693580
Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL [ Mol Med, 2022, 28(1):141] PubMed: 36435772
Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER Stress [ Biomolecules, 2022, 12(6)843] PubMed: 35740967
Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway [ FASEB J, 2021, 35(5):e21502] PubMed: 33811696
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. [ Nat Commun, 2020, 27;11(1):1620] PubMed: 32221306
Tetrandrine attenuates hyperoxia-induced lung injury in newborn rats via NF-κB p65 and ERK1/2 pathway inhibition [ Ann Transl Med, 2020, 8(16):1018] PubMed: 32953818
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. [ Cell Death Dis, 2019, 10(2):38] PubMed: 30674869

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。