Thioguanine

製品コードS1774 バッチS177404

印刷

化学情報

Chemical Structure Synonyms NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C5H5N5S
分子量 167.19 CAS No. 154-42-7
Solubility (25°C)* 体外 DMSO 8 mg/mL (47.84 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Thioguanine, a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.
in vitro

Thioguanine incorporation alters the DNA cleavage induced by topoisomerase II in the presence and absence of etoposide. [1] This compound alters the structure and lowers the thermal stability of duplex DNA, but duplex DNA can be formed in the presence of 6SG. [2] Its induced apopotosis is similarly observed in both mismatch repair-proficient and -deficient HCT116 and HeLa cells. [3] This chemical integrates into DNA and unlike the canonical DNA bases, it is a strong UVA chromophore with an absorbance maximum at 342 nm. It is a photosensitizer and a source of reactive oxygen species. [4] In canine lymphoma cells, this compound significantly decreases DNMT1 protein and global DNA methylation. [6]
in vivo

Thioguanine is as efficient as a PARP inhibitor in selectively killing BRCA2-defective tumors in a xenograft model. This compound efficiently kills such BRCA1-defective PARP inhibitor-resistant tumors. It could kill cells and tumors that have gained resistance to PARP inhibitors or cisplatin through genetic reversion of the BRCA2 gene. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/11053256/
  • https://pubmed.ncbi.nlm.nih.gov/10390526/
  • https://pubmed.ncbi.nlm.nih.gov/15788687/
  • https://pubmed.ncbi.nlm.nih.gov/20631063/
  • https://pubmed.ncbi.nlm.nih.gov/20631063/
  • https://pubmed.ncbi.nlm.nih.gov/25480665/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy [ BMC Microbiol, 2025, 25(1):53] PubMed: 39881250
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3] PubMed: 38262581
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862] PubMed: 39319271
Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma [ Cancers (Basel), 2024, 16(21)3606] PubMed: 39518046
Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals [ BMC Genomics, 2024, 25(1):1030] PubMed: 39497025
Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance [ Cancer Cell, 2023, 41(1):196-209.e5] PubMed: 36584674
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia [ Nat Commun, 2022, 13(1):6226] PubMed: 36266272
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia [ Nat Commun, 2022, 13(1):6226] PubMed: 36266272
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk [ Hepatology, 2022, 10.1002/hep.32802] PubMed: 36221953
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] PubMed: 35207746

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。