Topiramate

製品コードS1438 バッチS143801

印刷

化学情報

Chemical Structure Synonyms MCN 4853, RWJ 17021 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C12H21NO8S
分子量 339.36 CAS No. 97240-79-4
Solubility (25°C)* 体外 DMSO 68 mg/mL (200.37 mM)
Ethanol 68 mg/mL (200.37 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
in vitro Topiramate slightly inhibits the persistent fraction of Na+ current in dissociated neurons and reduces the Na+-dependent long-lasting action potential shoulders, which can be evoked in layer V pyramidal neurons after Ca+ and K+ current blockade in neocortical slices. [1] This compound at low concentrations (IC50, approximately 0.5 mM) selectively inhibits pharmacologically isolated excitatory synaptic currents mediated by kainate receptors containing the GluR5 subunit in whole-cell voltage-clamp recordings from principal neurons of the rat basolateral amygdala. It also partially depresses predominantly AMPA-receptor-mediated EPSCs, but with lower efficacy. [2] This chemical suppresses voltage-sensitive Na+ channels and non-N-methyl-D-aspartate (NMDA) receptors and enhances gamma-aminobutyric acid (GABA)-mediated inhibition. [3] It selectively inhibits postsynaptic responses mediated by GluR5 kainate receptors. [4]
in vivo Topiramate (25-100 mg/kg, i.p.) produces a dose-dependent elevation in the threshold for clonic seizures induced by infusion of ATPA, a selective agonist of GluR5 kainate receptors. [4] This compound effectively suppresses acute seizures induced by perinatalhypoxia in a dose-related manner with a calculated ED50 of 2.1 mg/kg, i.p. [5] It (20 and 40 mg/kg i.p.) inhibits both tonic and absence-like seizures in a dose-dependent manner, whereas Phenytoin (20 mg/kg i.p.) and Zonisamide (40 mg/kg i.p.) inhibits only the tonic seizures. This chemical inhibits sound-induced seizures in DBA/2 mice (ED50 = 8.6 mg/kg p.o.). [6]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10027832/
  • https://pubmed.ncbi.nlm.nih.gov/12904467/
  • https://pubmed.ncbi.nlm.nih.gov/9757028/
  • https://pubmed.ncbi.nlm.nih.gov/15111016/
  • https://pubmed.ncbi.nlm.nih.gov/11558793/
  • https://pubmed.ncbi.nlm.nih.gov/8206119/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Neural signature of chronic migraine mice model and related photophobia in the primary visual cortex [ J Headache Pain, 2025, 26(1):182] PubMed: 40796816
Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells [ Commun Biol, 2025, 8(1):28] PubMed: 39789216
Cancer genes disfavoring T cell immunity identified via integrated systems approach [ Cell Rep, 2022, 40(5):111153] PubMed: 35926468
A Low Dose of Aripiprazole Has the Strongest Sensitization Effect Among 19 Repositioned Bipolar Drugs in P-gp-overexpressing Drug-resistant Cancer Cells [ Anticancer Res, 2021, 41(2):687-697] PubMed: 33517273
The anticonvulsant zonisamide positively modulates recombinant and native glycine receptors at clinically relevant concentrations [ Neuropharmacology, 2020, 182:108371] PubMed: 33122032
Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine. [ Br J Pharmacol, 2018, 175(21):4154-4166] PubMed: 30079481

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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