Torsemide

製品コードS1698 バッチS169801

印刷

化学情報

Chemical Structure Synonyms AC-4464, JDL-464 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H20N4O3S
分子量 348.42 CAS No. 56211-40-6
Solubility (25°C)* 体外 4-Methylpyridine (warmed with 50ºC water bath) 30 mg/mL (86.1 mM)
DMSO (warmed with 50ºC water bath) 1 mg/mL (2.87 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
in vitro Torsemide inhibits aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. [1] This compound's primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na+, K+, 2Cl− cotransporter. It interferes with the secretion of, and receptor ligand binding of, the mineralocorticoid aldosterone in a dose-dependent manner. [2]
in vivo Torsemide results in elevated levels of circulating angiotensin II and aldosterone (supportive of interference with aldosterone at the receptor level) in dogs with experimental mitral regurgitation whereas furosemide results in elevated levels of angiotensin II, only. [2] This compound increases the BUN and plasma creatinine concentrations in rats, compared with the baseline value. It immediately increases urine volume significantly. [3]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/9698054/
  • https://pubmed.ncbi.nlm.nih.gov/22364690/
  • https://pubmed.ncbi.nlm.nih.gov/17916010/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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